An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #12329
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Novel proteinaceous infectious particles cause Scrapie.Science, 216 (4542),136–144., 1982.Prusiner won the Nobel Prize in Physiology or Medicine in 1997 for his work in proposing a completely novel explanation for the cause of bovine spongiform encephalopathy ("mad cow disease") and its human equivalent, Creutzfeldt–Jakob disease. To describe the cause of the disease in this paper published on April 9, 1982 Prusiner coined the term prion, which comes from the words "proteinaceous" and "infectious," to refer to a previously undescribed form of infection, due to protein misfolding, with no DNA or RNA involved. This new concept "violated all the rules" and failed to convince the scientific community, most of whom initially thought that Prusiner was "totally insane." Subjects: INFECTIOUS DISEASE › Prion Diseases, NEUROLOGY › Degenerative Disorders, VETERINARY MEDICINE Permalink: historyofmedicine.com/id/12329 |