An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #14134
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The agent of bacillary angiomatosis - An approach to the identification of uncultured pathogens.New Eng. J. Med., 323, 1573-1580, 1990.To identify an uncultured and unidentified pathogen that was often visualized in tissue sections of lesions of bacillary angiomatosis with Warthin-Starry staining, the authors utilized two different techniques that were innovative at the time: 16S ribosomal RNA analysis and PCR. This was seen as a milestone in the molecular identification of pathogens that could be "seen" but not cultured. The authors indicated in their abstract that "this bacillus may also cause cat scratch disease." They concluded that "The cause of bacillary angiomatosis is a previously uncharacterized rickettsia-like organism, closedly related to R. quintana. This method for the identification of an cultured pathogen may be applicable to other infectious diseases of unknown cause." Digital facsimile from nejm.org at this link. (Thanks to Juan Weiss for this reference and its interpretation.)
Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Bartonella, INFECTIOUS DISEASE › Animal Bite Wound Infections › Cat Scratch Fever, INFECTIOUS DISEASE › Bacillary Angiomatosis Permalink: historyofmedicine.com/id/14134 |