An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16591

  • 14270

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Nature, 399, 271-275, 1999.

The focus of both Peter Ratcliffe’s and William Kaelin’s work, for which they shared the Nobel Prize with Gregg Semenza, was the relationship between pVHL and HIF. This led to an increased understanding of how cells sense and adapt to changing oxygen levels.  Order of authorship in the original publication: Maxwell,...Pugh, Maher, Ratcliffe.

In 2019 Ratcliffe shared the Nobel Prize in Physiology or Medicine with William Kaelin, Jr. and Gregg Semenza "“for their discoveries of how cells sense and adapt to oxygen availability.”




Subjects: NOBEL PRIZES › Nobel Prize in Physiology or Medicine , PHYSIOLOGY
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