An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #16670
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Tuning the activity of an enzyme for unusual environments: Sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.Proc. Nat. Acad. Sci. (U.S.A.), 90 (12) 5618-5622, 1993.Arnold introduced a biochemical molecule manipulating technique to mimic the process of natural selection in creating new enzymes adapted to a specific catalytic reaction. She directed evolution of subtilisin E to obtain an enzyme variant which was active in a highly unnatural (denaturing) environment. In 2018 Arnold received half of the Nobel Prize in Chemistry "for the directed evolution of enzymes." Subjects: NOBEL PRIZES › Nobel Prize in Chemistry (selected), WOMEN, Publications by › Years 1900 - 1999 Permalink: historyofmedicine.com/id/16670 |