Browse by Entry Number 14200–14299
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Ultra-fast deep-learned CNS tumour classification during surgery.Nature, https://doi.org/10.1038/s41586-023-06615-2, 2023.Published "open access" 11 October 2023. https://www.nature.com/articles/s41586-023-06615-2 "Abstract Subjects: Artificial Intelligence in Medicine , NEUROSURGERY › Neuro-oncology |
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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.Nature, 543, 248-251, 2017.Prior to their development of the mRNA vaccine for Covid-19, Karikó and Weissman (Nobel Prize 2023) and colleagues used a novel mRNA vaccine, with base modifications created in their laboratory, to generate a protective Zika vaccine. From the abstract: “....Here we demonstrate that a single low-dose intradermal immunization with lipid nanoparticle-encapsulated nucleoside modified mRNA (mRNA-LPN), encoding the pre-membrane and envelope glycoproteins of a strain from the ZIKV outbreak in 2013, elicited potent and durable neutralizing antibody responses in mice and non-human primates....” In 2023 the full text of this paper was available from nature.com at this link. Subjects: INFECTIOUS DISEASE › VECTOR-BORNE DISEASES › Mosquito-Borne Diseases › Zika Virus Disease, VIROLOGY › VIRUSES (by Family) › Flaviviridae › Zika Virus |
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Mendelian inheritance in man; catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes.Baltimore, MD: The Johns Hopkins University Press, 1966.Last expanded printed edition: 12th edition, 3 vols., 1998. Subjects: GENETICS / HEREDITY › GENETIC DISORDERS |
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The anemias.London: Oxford University Press, 1934.Subjects: HEMATOLOGY › Anemia & Chlorosis |
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A medico-legal treatise on malpractice and medical evidence, comprising the elements of medical jurisprudence.New York: John A. Voorhies, 1860.The first treatise on malpractice published in the United States and the first book to provide observations on the physician as an expert witness in malpractice cases. Digital facsimile from wellcomecollection.org at this link. Subjects: LAW and Medicine & the Life Sciences, LAW and Medicine & the Life Sciences › Malpractice |
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Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.Science, 303, 1669-1674, 2004.The authors in Korea, led by Woo-suk Hwang, reported the cloning of a human blastocyst using somatic cell nuclear transfer, and deriving pluripotent embryonic stem cells from that cloned blastocyst. In doing so they claimed to have cloned the first human being. Numerous extensive scientific investigations resulting from testimony of the second author, Young June Ryu, resulted in an official "Editorial Retraction" published in Science, 311, 2006, p.335. At that time only 7 of the 12 co-authors of the paper agreed to retract their claims. Subjects: Crimes / Frauds / Hoaxes, EMBRYOLOGY |
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Experimental evidence in support of an extra-terrestrial trigger for the Cretaceous-Tertiary extinctions. (Abstract).Eos, 60, p. 734, 1979.Iridium is a very rare element in the Earth's crust, but is found in anomalously high concentrations (around 1000 times greater than normal) in a thin worldwide layer of clay marking the boundary between the Cretaceous and Paleogene periods 66 million years ago. This boundary marks a major extinction event, including extinction of the dinosaurs along with about 70% of all other species. In 1979 the physicist Luis Alvarez, his son, geologist Walter Alvarez, and chemists Frank Asaro and Helen Vaughn Michel were the first to link the extinction to an extraterrestrial impact based on the observation that iridium is much more abundant in meteorites than it is on Earth. During 1979 dozens of newspapers and magazine articles presented the original Alvarez hypothesis on the basis of only a talk at the American Geophysical Union meeting (Washington, May 1979) and accompanying abstract cited here. Subjects: BIOLOGY › Ecology / Environment › Climate Change, BIOLOGY › Evolution, Geology, Medical & Biological |
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Extraterrestrial cause for the Cretaceous-Tertiary extinction.Science, 208, 1095-1108, 1980.Following up on No. 14206, the authors stated that the same excess iridium areas were found in two different areas of W. Europe and in New Zealand, and posited that “the anomalous iridium concentrations at the C [retacous]-T[ertiary] boundary is best interpreted as indicating an abnormal influx of extraterrestrial material.” They suggested that this was produced by an asteroid strike on the earth that formed an impact crater, and that some of the dust sized material about 60 times the object’s mass would eject and inject the stratosphere with pulverized dust containing iridium which would then spread around the globe. This dust from the explosion would have blocked sunlight for a long time and suppressed photosynthesis, and as a result most food chains would have collapsed, and extinctions resulted. Luis Alvarez calculated the size of the asteroid needed to produce the catastrophic impact -- an asterioid with a diameter of about 10 plus or minus 4 kilometers at the entry velocity that meteorites hit earth. They pointed out that “an asteroid of 10 km. diameter is twice the typical oceanic depth and this would produce a crater on the ocean bottom, and pulverized rock could be ejected.” They estimated that no terrestrial vertebrate heavier than about 25kg. would have survived the extinction. Finally they stated that the crater resulting from such a collision must be found to validate their hypothesis, and “there is about a 2/3 probability that this object fell in the ocean.” Subjects: BIOLOGY › Ecology / Environment › Climate Change, BIOLOGY › Evolution, Geology, Medical & Biological |
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Chicxulub Crater: A possible Cretaceous/Tertiary boundary impact crater on the Yucatán Peninsula, Mexico.Geology, 19, 867-871, 1991.Eleven years after publication of No. 14207, Alan Hildebrand, working with Luis and Walter Alvarez, proposed that the Chicxulub Crater, discovered by Antonio-Camargo-Zanoguera and Glen T. Penfield during the 1970s, was the C-T boundary impact crater posited in No. 14207. "ABSTRACT: We suggest that a buried 180-km-diameter circular structure on the Yucatan Peninsula, Mexico, is an impact crater. Its size and shape are revealed by magnetic and gravity-field anomalies, as well as by oil wells drilled inside and near the structure. The stratigraphy of the crater includes a sequence of andesitic igneous rocks and glass interbedded with, and overlain by, breccias that contain evidence of shock metamorphism. The andesitic rocks have chemical and isotopic compositions similar to those of tektites found in Cretaceous/Tertiary (K/T) ejecta. A 90-m-thick K/T boundary breccia, also containing evidence of shock metamorphism, is present 50 km outside the crater's edge. This breccia probably represents the crater's ejecta blanket. The age of the crater is not precisely known, but a K/T boundary age is indicated. Because the crater is in a thick carbonate sequence, shock-produced CO 2 from the impact may have caused a severe greenhouse warming." Subjects: BIOLOGY › Ecology / Environment › Climate Change, BIOLOGY › Evolution, Geology, Medical & Biological |
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U. S. Plant patent 1. Climbing or trailing rose. Filed Aug. 6, 1930. Issued Aug. 18, 1931.1931.This was the first patent granted for a life form. In response to complaints from the nursery industry that the future of the plant breeding industry was jeopardized by the “pirating” of new plant varieties, President Herbert Hoover signed The Plant Patent Act into law on 23 May 1930. Bosenberg's patent consists of a single black & white drawing of the rose plus one page of claims. Subjects: BOTANY, LAW and Medicine & the Life Sciences › Patents |
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Die Deutsche [sic] Giftpflanzen, zur Verhütung der tragischen Vorfälle in den Haushaltungen, nach ihren botanischen Kennzeichen, nebst den Heilungsmitteln.Berlin: Joachim Pauli, 1784.On poisonous plants in Germany, for prevention of tragic household accidents, and remedies for the poisons. Illustrated with 16 plates. Subjects: BOTANY › Medical Botany, Household or Self-Help Medicine, TOXICOLOGY |
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De l'Atténuation des virus, avec la collaboration de MM. Chamberland, Roux et Thuillier. Quatrième Congrès international d'hygiène et de démographie. Séance du 5 Septembre 1882.Geneva: H. Georg, 1883.In his seminal 1880 paper, Sur les maladies virulentes, et en particulier sur la maladie appelée vulgairement choléra des poules, GM-2537, Pasteur developed the idea of a protective inoculation by attenuated living cultures, and subsequently adopted this principle with anthrax, rabies, and swine erysipelas. His work laid the foundations of the science of immunology. However, in that paper Pasteur did not reveal his method of attenuation until this paper presented in September 1882, and first published in 1883. The method developed by Pasteur and his team was "heating the anthrax bacillus at exactly between 42 and 43 degrees centigrade for at least 5-6 hours.” Toward the end of his paper they stated, “It cannot be doubted that we possess a general method of attenuation…." Subjects: IMMUNOLOGY › Vaccines, VIROLOGY |
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Evidence for plasmid mediated toxin production in Bacillus anthracis.Infection and Immunity, 39, 371-376, 1983.The authors illustrated and proved that “heating V770-NPI-R containing anthrax strains, to exactly 42.5 degrees centigrade, as Pasteur and colleagues reported in GM 14211, essentially ‘cured’ these strains of their plasmid and caused a loss of detectable lethal toxin.” Near the end of their paper they stated, “In assessing Pasteur’s experimental regimen, and by utilizing modern techniques, we are able to offer a reasonable explanation for a century old molecular event which has had such a significant impact in the field of medical microbiology and it is Subjects: IMMUNOLOGY › Vaccines, VIROLOGY |
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Ueber die Textur und Function der Medulla oblongata. 2 vols. (Text and atlas).Erlangen: Ferdinand Enke, 1843.“In this book, there are many transverse section figures from the origin of the 2nd cervical nerve pair up to the pons. Stilling aimed to reveal the difference between the spinal cord and medulla oblongata by presenting in detail the anatomical structures in his figures” (Demircubuk, Ibrahim, et al. “The Seminal Contributions of Benedict Stilling (1810–1879) to Neuroanatomy.” Child’s Nervous System. SpringerLink, Springer Berlin Heidelberg, 31 Mar. 2022 (web). Subjects: ANATOMY › Neuroanatomy |
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Neue Untersuchungen über den Bau des Rückenmarks. 2 vols. (Text and atlas.)Cassel: Heinrich Hotop, 1859.Stilling carried out some of the 19th century’s most detailed and precise examinations of the spinal cord, which “laid the foundation for the modern anatomical study of the spinal cord, medulla oblongata, and pons” (Clarke & O’Malley, p. 834). Stilling was the first to use serial sections to study the spinal cord’s inner structure, slicing frozen or alcohol-hardened cords into thin slices to be studied under the microscope or with the naked eye. In 1859 he published his enormous and detailed Neue Untersuchungen über den Bau des Rückenmarks [New researches on the structure of the spinal cord], containing the results of his seventeen years of study, along with detailed instructions on his methods for preparing both transverse and longitudinal spinal cord sections. The atlas contains some of the most dramatic plates of the spinal cord ever published, including one enormous and highly detailed folding lithograph of a single spinal cord cross-section. The text consists of 1192 pages plus 108 pages of explanations of the 31 plates. Subjects: ANATOMY › Neuroanatomy |
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Elements of operative midwifery.London: Hurst, Robinson, 1825.Davis introduced a number of improvements in instruments and techniques: “It outlines rules and precautions for undertaking operations, described the use of various forms of forceps, and provided twenty detailed plates, [some of them] illustrating techniques of craniotomy using the crochet and Denman’s perforator” (Woods, Death before birth: Fetal health and mortality in historical perspective, p. 138). Subjects: OBSTETRICS & GYNECOLOGY › GYNECOLOGY |
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Hammond's wall atlas of human anatomy.Maplewood, NJ: C. S. Hammond & Co., 1970.With pages measuring 731 x 536 mm., this is the largest anatomical atlas ever published with plastic overlays. The covers include metal grommets so that the book could be hung on the wall. The work was undated, but is estimated to have been published around 1970. Subjects: ANATOMY › 20th Century |
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Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.Nature, 423, 293-298, 2003.The authors showed that mutations in lamin A (LMNA) are the cause of Hutchinson-Gilford progeria sundrom (HGPS). At the end of their abstract they stated that "The discovery of the molecular basis of this disease may shed light on the general phenomenon of human aging." Subjects: BIOLOGY › MOLECULAR BIOLOGY › Molecular Biology, GENETICS / HEREDITY › GENETIC DISORDERS › Progeria |
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In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.Nature, 589, No. 7843, 608-614, 2021.Using the base editor enzyme developed by Liu (GM11865), the authors report that they can “correct the pathogenic HGPS mutation in cultured fibroblasts derived from children with progeria and in a mouse model of HGPS.” Their technique resulted in “87-91% correction of the pathogenic allele, mitigation of the resulting RNA mis-splicing, reduced levels of progerin and correction of the nuclear abnormalities.” Mice treated like this, exhibited “improved vitality and greatly extended median lifespan from 215 to 510 days.” At the end they added that “these findings demonstrate the potential of in vivo base editing as a possible treatment for HGPS and other genetic diseases by directly correcting their root cause.” Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR Gene Editing, GENETICS / HEREDITY › GENETIC DISORDERS › Progeria |
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Jean Fery: A sixteen century case of dissociative identity disorder.Journal of Psychohistory, 24, 18-35, 1996.Abstract: "This discussion reinterprets a sixteenth-century case of possession and exorcism ashttps://archive.org/details/lapossessiondeje00bour/page/n7/mode/2up Dissociative Identity Disorder (DID), formerly known as Multiple Personality Disorder (MPD). This is perhaps the earliest historical case in which DID can be diagnosed retrospectively with confidence. Jeanne Fery, a 25-year-old Dominican Nun, wrote her own account of her exorcism which took place in Mons, France in 1584 and 1585. Her exorcists produced an even more detailed account describing both identity fragmentation and a past history of childhood trauma. Also well described in both accounts are major criteria and associated features of DID as described in present day diagnostic manuals (American Psychiatric Association, 1987, 1994.) The 109-page description of her treatment course was republished in French in the nineteenth century by Bourneville (1886), a colleague of Janet, who also diagnosed Jeanne's disorder as "doubling of the personality," (the term then in use for DID). This article is the first English- language presentation of these documents." Subjects: PSYCHIATRY › Dissociative Identity Disorder |
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Medicinal plants of Central Asia: Uzbekistan and Kyrgystan.New York: Springer, 2012.
"... the first English-language book detailing medicinal plant diversity in the region. More than two hundred of the most important medicinal plants of Central Asia are listed and it includes many whose medicinal uses and activities are being compiled for the first time. Information on the taxonomy, morphology, ecology, ethnobotany, chemistry, and pharmacology of plants from this region are presented with hundreds of beautiful color photographs. The book is co-authored by scientists from Kyrgyzstan, Uzbekistan and the U.S. and draws upon a rich source of local knowledge. The extensive English-Russian linguistic glossary to ecological, botanical, chemical, and medical terms is the first of its kind for this type of book" (publisher).
Subjects: BOTANY › Medical Botany › Medical Botany |
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The Kirtsos historical library of Homoeopathic medicine: An annotated bibliographical catalogue.Novato, California: Norman Publishing & Old Chatham, New York: Athenaeum Homeopathia, 2023.The definitive bibliographical catalogue of the historical literature of homeopathy. Subjects: ALTERNATIVE, Complimentary & Pseudomedicine › Homeopathy › History of Homeopathy, BIBLIOGRAPHY › Bibliographies of Specific Subjects |
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Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.New Eng. J. Med., 295, 417-420, 1976.The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood Subjects: Laboratory Medicine, Metabolism & Metabolic Disorders › Diabetes |
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The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method.Proc. roy. Soc. Ser. A. Math. & Phys. Sci, 225, 287-307, 1954.The first demonstration of isomorphous replacement in protein crystallography. This was a key step in determination of the structure of large biological molecules. Harittai, "On the origins of isomorphous replacement in protein crystallography," Structural Chemistry, 33, 2022, 635-639. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Crystallization |
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The crystallization of ribsomal proteins from the 50 S subunit of the Escherichia coli and Bacillus stearothermophilus ribosome.J. biol. Chem, 256, 11787-11790, 1981.The authors crystallized fragments of the 50S subunit of a thermophile bacterium’s ribosome to 3 angstroms resolution. Yonath shared the 2009 Nobel Prize in chemistry with Ventatraman Ramakrishnan and Thomas Steitz "for studies of the structure and function of the ribosome." Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Crystallization, BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis |
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Brass plate and brazen impudence: Dental practice in the provinces 1755-1855.Liverpool: Liverpool University Press, 1991.Subjects: DENTISTRY › History of Dentistry |
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Dental practice in Europe at the end of the 18th century. Edited by Christine Hilliam.Leiden: Brill, 2003.Subjects: DENTISTRY › History of Dentistry |