An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15957 entries, 13939 authors and 1935 subjects. Updated: February 16, 2024

KOLYKHALOV, Alexander M

1 entries
  • 13541

Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.

Science, 277, 570-74, 1997.

Rice (Nobel Prize 2020) and colleagues constructed a viral RNA genome with the 3’ region and a consensus region to exclude potential inactivating mutations, which was then injected into the liver of chimps. That RNA, specifically encoded for the Hepatitis C virus (HVC), established a productive infection, and a clinical hepatitis resulted. Infectious virus was found in chimps' blood for several months from this "non mutation prone and ultrapure" RNA genome, which coded bonafide virus and also provoked the specifically expected antibody response. 

Order of authorship in the original publication:  Kolyphalov, Agapov..., Rice.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis C Virus