An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15957 entries, 13939 authors and 1935 subjects. Updated: February 16, 2024

POLTORAK, Alexander

1 entries
  • 12112

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the Tlr4 gene.

Science, 282, 2085-2088, 1998.

Order of authorship in the original paper: Poltorak, Smirnova...Beutler. The authors, led by Beutler, showed that mice that harbor a mutation of the gene which codes for the production of the Toll-like receptor TLR4 quickly die of sepsis if challenged with a Gram-negative pathogen because they cannot sense the Lipopolysaccharides (LPS), also known as endotoxins, found in the outer membrane of Gram-negative bacteria, and, for that reason, cannot mount an adequate immune response. 

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: IMMUNOLOGY › Molecular Immunology