SØRENSON, Anne L.
1 entries
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Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.Infection and Immunity, 63, 1710-1717, 1995.Andersen and colleagues found that a protein fraction obtained from M. tuberculosis was immunologically active in mice, suggesting that it was one of the proteins recognized by T cells. In this paper the authors identified and purified the active protein, ESAT-6, and showed that it consists of 95 amino acids. This work and that of Mahairas and colleagues (No. 11995) led to a new test called the Interferon gamma release assay. (Thanks to Ron Cox for this reference and its interpretation.) Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Positive Bacteria › Mycobacterium › Mycobacterium tuberculosis, IMMUNOLOGY › Immunization, INFECTIOUS DISEASE › Tuberculosis |