An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16011 entries, 14068 authors and 1941 subjects. Updated: June 19, 2024

KOBILKA, Brian Kent

2 entries
  • 14134

Crystal structure of the β2 adrenergic receptor–Gs protein complex.

Nature, 477, 549-555, 2011.

Kobilka and colleagues published the crystal structure of a beta-2 receptor forming a complex with the G protein coupled receptor. This was the first time that a complete complex of an active receptor and it's Gs protein partner were crystallized.They also described some’of the basic molecular interactions of a beta receptor and G protein coupled receptors. The image of this crystallographic complex that they published was described by more romantic molecular biologists as “the first image of the receptor locked in an embrace with its protein partner.” Order of authorship in the original publication: Rasmussen, Devree....Kobilka.

In 2012 Kobilka shared the Nobel Prize in Chemistry with Robert J. Lefkowitz "for studies of G-protein-coupled receptors."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors, NOBEL PRIZES › Nobel Prize in Chemistry
  • 14135

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.

Nature, 477, 611-615, 2011.

Using X ray crystallographic techniques and electron microscopy, Kobilka (Nobel Prize 2012) and colleagues described the very complex nucleotide exchange and interactions at the molecular level of the alpha subunit of a Gs at the moment of its activation by an adrenergic receptor. 
The authors showed that the structural links between the receptor binding surface and the nucleotide binding pocket of the Gs undergo higher levels of hydrogen deuterium exchange than would have been predicted from the crystal structure of the beta 2 adrenergic receptor-Gs complex. Then the team, using advanced computer techology, explained the complex molecular interactions between these two molecules, revealing many details that were neither expected nor predicted before this achievement.

Order of authorship in the original publication: Chung, Rasmussen, ...Kobilka....

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors