An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16018 entries, 14076 authors and 1941 subjects. Updated: July 14, 2024

BOLTON, David C.

1 entries
  • 10842

Identification of a protein that purifies with the Scrapie prion.

Science, 218, 1309-1311, 1982.

Research with the biochemist Bolton enabled Prusiner to discover and characterize the specific protein causing prion disease. This paper was dated December 24, 1982.

Nearly simultaneously, Prusiner and the same co-authors published an additional, longer paper dated December 21, 1982, further characterizing the pure protein of the infectious agent:

"Further purification and characterization of Scrapie prions," Biochemistry, 21 (1982) 6942-6950. 

These papers provided the necessary evidence to convince members of the scientific community, and eventually led to Prusiner's Nobel Prize.

(Thanks to Juan Weiss for these references and their interpretation.)