First clinical and experimental proof of infection by a microparasite. Bonomo observed Sarcoptes scabiei, the scabies mite. This gave researchers grounds to think in terms of objective, exogenous pathogenic agents as the cause of disease. This pamphlet was in part translated by Richard Mead in Phil. Trans.,(1702-03), 1703, 23, 1296-99; it was reproduced in facsimile, with Mead’s translation, in Arch. Derm. Syph. (Chicago), 1928, 18, 1-25. See 2529.1.