An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: November 17, 2024

SMITH, Hamilton Othanel

3 entries
  • 6889

A restriction endonuclease from Hemophilus influenzae. II. Base sequence of the recognition site.

J. Mol. Biol., 53, 393-409, 1970.

Discovery of the first type II restriction enzyme (HindII).

Smith shared the 1978 Nobel Prize in Physiology or Medicine with Werner Arber and Daniel Nathans "for the discovery of restriction enzymes and their application to problems of molecular genetics."

Also: Smith H.O., Wilcox, K.W. , "A restriction enzyme from Hemophilus influenzae. I. Purification and general properties," J. Mol. Biol. 51 (1970) 379-391.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics, BIOLOGY › MOLECULAR BIOLOGY › Restriction Enzyme or Restriction Endonuclease, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
  • 11343

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Science, 269, 496-512, 1995.

First sequence of the complete genome of a free-living non-viral organism—Haemophilus influenzae—the bacterium that causes lower respiratory tract infections and meningitis in infants and young children. This genome consisted of 1,830,137 base pairs. Order of authorship in the original publication: Fleischmann, Adams, White....Smith, Venter. 

Digital facsimile from biology.iupui.edu at this link.



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Haemophilus, BIOLOGY › MOLECULAR BIOLOGY › Genomics › Pathogenomics, INFECTIOUS DISEASE › Influenza, NEUROLOGY › Inflammatory Conditions › Cerebrospinal Meningitis, PEDIATRICS
  • 11342

Complete genome sequence of treponema pallidum, the syphilis spirochete.

Science, 281, 375-388, 1998.

Order of authorship in the original publication: Fraser, Norris, Weinstock....Smith, Venter.  Sequence of the genome of the bacterium that causes syphilis.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Spirochetes › Treponema , BIOLOGY › MOLECULAR BIOLOGY › Genomics › Pathogenomics, INFECTIOUS DISEASE › SEXUALLY TRANSMITTED DISEASES › Syphilis, WOMEN, Publications by › Years 1900 - 1999