An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: April 29, 2024


1 entries
  • 14151

Dynamic basis for dG•dT misincorporation via tautomerization and ionization.

Nature, 554, 195-201, 2018.

In 1953 Watson and Crick proposed that rarely formed isomers of DNA bases cause spontaneous mutations to occur during the copying of DNA. Such mutations would be easily accommodated because tautomeric mispairs do not distort the helical DNA structure. The disfavored-tautomer model for spontaneous mutation formation (mutagenesis) was rapidly adopted by biologists and included in textbooks, despite the absence of supporting experimental evidence. In 2018 Kimsey, Al-Hashimi and colleagues showed that Watson's and Crick's prediction was correct.
Digital text from PubMedCentral at this link.

Order of authorship in the original publication: Kimsey, Szymanski....Al-Hashimi.

(Thanks to Juan Weiss for this reference and its interpretation.)