An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16027 entries, 14091 authors and 1941 subjects. Updated: August 10, 2024

MATSUO, Hisayuki

1 entries
  • 14231

Structure of the porcine LH-and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Biochemical and Biophysical Research Communications, 44, 459-463, 1971.

Publication in May 1971:
Working with pig preparations, the authors reinvestigated the peptide that they had previously isolated, which acted as an LH-FSH releasing hormone. They performed an Edman-dansyl degradation procedure on the substance. This resulted in “amino acid sequence of porcine LH-RH/FSH-RH is thus (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.”

Publication in September 1971: 
A.V. Schally, A. Arimura, A.J. Kastin et. al., Gonadotropin-Releasing Hormone: One polypeptide regulates secretion of luteinizing and follicle-stimulating hormones, Science, 173, 1971, 1036-1037.

         The Authors proved that the peptide discovered and sequenced by them in May of 1971 is the substance capable of stimulating release of LH and FSH. They synthesized the substance and compared its physiological action to the native peptide found in the pig. When they compared the action of both they found them identical, and stated “when they chemically or enzymatically inactivate the synthesized LH-RH they observe a loss of FSH-releasing activity,” an irrefutable proof of its physiological action.

In 1977 Schally shared half of the Nobel Prize in Physiology or Medicine with Roger Guillemin "for their discoveries concerning the peptide hormone production of the brain." The other half was awarded to Rosalyn Yalow for "for the development of radioimmunoassays of peptide hormones."

(Thanks to Juan Weiss for these references and their interpretation.)



Subjects: ENDOCRINOLOGY, NOBEL PRIZES › Nobel Prize in Physiology or Medicine