An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15791 entries, 13704 authors and 1919 subjects. Updated: September 13, 2022

HORVITZ, Howard Robert

3 entries
  • 9938

Post-embryonic cell lineages of the nematode Caenorhabditis elegans.

Developmental Biology, 56, 110-156., 1977.

Complete map of the nematode's neurons. Sulston and Horvitz tracked every non-gonadal cell division that occurred during larval development, and published a complete description of these lineages in 1977.



Subjects: BIOLOGY › Developmental Biology, BIOLOGY › MOLECULAR BIOLOGY
  • 9939

Genetic control of programmed cell death in the nematode C. elegans.

Cell, 44, 817-829., 1986.

Using C. elegans to investigate whether there was a genetic program controlling cell death, or apoptosis,  In 1986, Horvitz identified the first "death genes", ced-3 and ced-4. He showed that functional ced-3 and ced-4 genes were a prerequisite for the execution of cell death.



Subjects: BIOLOGY › Developmental Biology, BIOLOGY › MOLECULAR BIOLOGY
  • 9940

Mechanisms and functions of cell death.

Annual Review of Cell Biology, 7, 663-698., 1991.

Horvitz and colleagues identified several key components in the molecular pathway of programmed cell death, including: EGL-1, a protein which activates apoptosis by inhibiting CED-9.



Subjects: BIOLOGY › Cell Biology, BIOLOGY › Developmental Biology, BIOLOGY › MOLECULAR BIOLOGY