See also: Fries & Rothman, "Transitent activity of Golgi-like membranes as donors of vescular stomatitis viral glycoprotein in vitro," J. Cell. Biol., 90, 1981, 697-704.

"Rothman's research^[15] details how vesicles—tiny sac-like structures that transport hormones, growth factors, and other molecules within cells—know how to reach their correct destination and where and when to release their contents. This cellular trafficking underlies many critical physiological functions, including the propagation of the cell itself in division, communication between nerve cells in the brain, secretion of insulin and other hormones in the body, and nutrient uptake. Defects in this process lead to a wide variety of conditions, including diabetes and botulism " (Wikipedia article on James Rothman).