The first state pharmacopeia issued in the United States. Jackson and Warren were the "Committee for the Pharmacopoeia." Digital facsimile from the Internet Archive at this link.

The first monograph on heart disease written and published in the United States. Digital text from Project Gutenberg at this link.

This work, illustrated with 5 plates, contains several clear and minute descriptions of dislocation of the hip joint. In the course of the monograph Warrenproved the possibility of a type of dislocation that was denied by Astley Cooper, yet observed by several distinguished surgeons. Warren went to the trouble of publishing this monograph, not to disprove Astley Cooper, but to present his professional opinion in a malpractice case. 

"After realizing that his hip would never be right again, Charles Lowell decided to sue his local physicians (disregarding multiple doctors’ pleas to reconsider). He accused Hawkes of neglect and failing to initially reduce the dislocation, while he brought Faxon up on charges for having tried to manipulate the dislocation without the necessary medical training. Prior to 1987, defendants were not permitted to testify on their own behalf, and if Faxon had not been likewise accused, Hawkes could have easily put him on the stand to protect him as he was the only other medical practitioner present at the time of the incident (Harvey 1991, 175). The court case Lowell vs. Faxon and Hawkes was brought to trial on three occasions, and no concrete verdict was ever returned. The first trial, held in June of 1822 at the Superior Court for Washington County, Maine under Justice David Perham ruled in Lowell’s favor. The Judge charged Faxon and Hawkes $1962, who promptly appealed the case and brought it to the Supreme Court at Machias. The second trial, overseen by Chief Justice Prentiss Mellen, took place three months later in September of 1822. The jury, however, was highly influenced by outside politics not directly associated with case itself, and was unable to come to any agreement. They were divided, not only by the loyalties and biases between Massachusetts and Maine (the later had only seceded in 1820), but also on a more micro scale between Washington County in northern Maine and the surrounding areas (Spaulding 1910, 9). The doctors in this trial can be clearly grouped into opposing sides: all Bostonian doctors in favor of the plaintiff; all doctors from Maine supporting the defense. Amongst the smaller sphere of Maine residents, players can likewise be separated: Hawkes from Eastport (to whom whose residents felt a great sense of loyalty), and Lowell from outside the County lines. Consequently, the case was brought to court a final time in June of 1824. Once again, however, it came to a stale mate, and Justice Nathan Weston decided that “the best thing for all parties was for the plaintiff to accept a non-suit and the defendant to take no costs' (Spaulding 1910, 23)." Nobody wins. (https://collections.countway.harvard.edu/onview/exhibits/show/lowellhip/overview).

 Digital facsimile from the Hathi Trust at this link.

Operation in May 1824 – the first staphylorraphy in America – performed without direct knowledge of Roux’s operations. Nathan Smith (1762-1829) published an earlier paper on staphylorrhaphy in America: Am. med. Rev., 1826, 3, 396.

The petition to the Massachusetts legislature to legalize "the procuring of subjects for anatomical dissections" (from George Hayward's printed notice on the verso of the title page). Nine members of the Massachusetts Medical Society signed their names in type to this petition, including John Collins Warren, who was largely responsible for the passage of the Massachusetts Anatomy Act of 1831. (No. 11759). Digital facsimile from the U.S. National Library of Medicine at this link.

The first North American book on tumors, with 16 hand-colored plates by David Claypoole Johnston (1799-1865).

An expanded version of a lecture first delivered and published as a pamphlet in 1830. This is the first edition in book form, and one of the first American works on the value of exercise for the preservation of health. Digital facsimile from the Hathi Trust at this link.

Warren performed the first surgical operation under anesthesia at Massachusetts General Hospital on October 16, 1846. This work presents his experience with anesthesia in the year following. Digital facsimile from U.S. National Library of Medicine at this link.

“On October 16, 1846, at Massachusetts General Hospital, Warren participated in the first public demonstration of anesthesia for surgery. He was the surgeon for the first surgical patient given ether anesthesia, and William T. G. Morton was the anesthetist…. More than a year later, in November 1847, Sir James Young Simpson of Edinburgh discovered the anesthetic properties of chloroform. However, on January 28, 1848, the first fatal chloroform anesthesia was reported. Within a year, reports of more than 10 such cases appeared. As an authority on surgical anesthesia, Warren was often asked by concerned physicians about the safety of this new anesthetic. To draw his own conclusions, Warren reviewed and analyzed all of the fatal cases of chloroform anesthesia….Because of the potential hazards of chloroform, Warren proposed that the agent not be used in minor surgical cases and encouraged its substitution with chloric ether and sulfuric ether” (Sim, The Heritage of Anesthesia, pp. 85-86, 135). 

(Thanks to Malcolm Kottler for this reference.)