An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15791 entries, 13704 authors and 1919 subjects. Updated: September 13, 2022

GRIFFITH, John Stanley

1 entries
  • 12833

Self replication and scrapie.

Nature, 215, 1043-1044, 1967.

Griffith discussed complex physical chemistry mechanisms by which the scrapie agent could arise from information encoded in protein structure which could then be transferred to other protein molecules. He also considered means by which the same protein might take up different conformations (some being disease related) without changes in its primary structure, and the polymerization of the protein might provide it with different biological properties. He hypothesized that protein could undergo "self replication."

(Thanks to Juan Weiss for this reference and its interpretation.)


Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, INFECTIOUS DISEASE › Prion Diseases