An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15791 entries, 13704 authors and 1919 subjects. Updated: September 13, 2022

LEDERBERG, Joshua

7 entries
  • 255.4

Gene recombination in Escherichia coli.

Nature, 158, 558, 1946.

Discovery of sexual processes in the reproduction of bacteria. Lederberg shared the Nobel Prize with Tatum and Beadle (No. 254.3) in 1958.



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Escherichia coli, GENETICS / HEREDITY
  • 256.1

Genetic exchange in Salmonella.

J. Bact., 64, 679-99, 1952.

Description of a new mechanism (“transduction”) for the transfer of genetic characters from one bacterial strain to another.



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Negative Bacteria › Salmonella, BIOLOGY › MOLECULAR BIOLOGY
  • 9719

Replica plating and indirect selection of bacterial mutants.

Journal of Bacteriology, 63, 399-406, 1952.

Demonstration of the mutational basis of antibiotic resistance. Digital facsimile from PubMedCentral at this link.



Subjects: BACTERIOLOGY, PHARMACOLOGY › Drug Resistance, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics
  • 13970

Genetic exchange in salmonella.

J. Bacteriol., 64, 679-699, 1952.

Working as a graduate student with Lederberg, Zinder discovered that a bacteriophage can carry genes from one bacterium to another. Initial experiments were carried out using Salmonella. Zinder and Lederberg named this process of genetic exchange transduction. Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector. It is a common tool used by molecular biologists to stably introduce a foreign gene into a host cell's genome. Digital facsimile from PubMedCentral at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY
  • 8174

HPP-64-1 DENDRAL-64-A system for computer construction, enumeration and notation of organic molecules as three structures and cyclic graphs. Interim report to the National Aeronautics and Space Administration, December 15, (1964).

1964.

DENDRAL is considered the first expert system because it automated the decision-making process and problem-solving behavior of organic chemists. The project consisted of research on two main programs, Heuristic Dendral and Meta-Dendral,[4] and several sub-programs. It was written in Lisp (programming language). Digital facsimile from the National Library of Medicine at this link.



Subjects: Artificial Intelligence in Medicine , BIOCHEMISTRY, COMPUTING/MATHEMATICS in Medicine & Biology
  • 8175

Applications of artificial intelligence for organic chemistry: The Dendral project.

New York: McGraw-Hill, 1980.


Subjects: Artificial Intelligence in Medicine , BIOCHEMISTRY, COMPUTING/MATHEMATICS in Medicine & Biology
  • 10195

A history of gene transfer and therapy by Jon A. Wolff and Joshua Lederberg in: Wolff, Jon A. (ed.) Gene therapeutics: Methods and applications of direct gene transfer, pp.3-25.

Boston, MA: Birkhäuser, 1994.

Valuable for its detailed, but highly compressed discussion of the earliest history of these subjects, co-authored by Lederberg, who played a significant role during that period.



Subjects: GENETICS / HEREDITY, GENETICS / HEREDITY › Gene Therapy / Human Gene Transfer