An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15972 entries, 13969 authors and 1940 subjects. Updated: June 16, 2024

BURTON, Joshua N.

1 entries
  • 14101

The haplotype-resolved genome and epigenome of the aneuploidy HeLa cancer cell line.

Nature, 500, 207-211, 2013.

Adey and colleagues sequenced the haplotype-resolved whole genome of the HeLa cancer cell line. This showed a highly rearranged region at chromosome 8q24.21, where an integration locus of the HPV (human papillomavirus, type 18) was found, making it responsible both for her cervical carcinoma and death, and the immortalizing properties of this cell line. The authors also showed that this integrated HPV-18 genome caused a strong activation of the common proto-oncogene now known as Myc which is responsible for the carcinogenic action of the virus.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › Cell Biology, BIOLOGY › MOLECULAR BIOLOGY › Genomics, ONCOLOGY & CANCER › Carcinoma