Houssay and Fasciolo transplanted an ischemic kidney into an animal from which both kidneys had been removed. Hypertension resulted after establishment of circulation, supporting the view that hypertension is due to a chemical substance with pressor action produced in the ischemic kidney. They later showed that the ischemic kidneys of hypertensive dogs contained an excess of renin. See also Biol. Acad. nac. Med. B. Aires, 1937, 34, 342; J. Physiol. (Lond.), 1938, 94, 281.