An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15871 entries, 13811 authors and 1928 subjects. Updated: March 19, 2023


2 entries
  • 7802

The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues.

J. Pharmacol. Exp. Ther., 94, 22–28, 1948.

Brodie and Axelrod confirmed that paracetamol, also known as acetaminophen, was the major metabolite of acetanilide in human blood, and established that it was efficacious an analgesic. Unlike its precursors, paracetamol does not cause methemoglobinemia in humans. See also their follow-up papers:  "The fate of acetanilide in man" (PDF). J. Pharmacol. Exp. Ther., 94 (1948) 29–38., and Flinn, Frederick B., Brodie, B. B., "The effect on the pain threshold of N-acetyl p-aminophenol, a product derved in the body from acetanilide", J. Pharmacol. Exp. Ther., 94 (1948) 76-77.

Subjects: PAIN / Pain Management, PHARMACOLOGY › PHARMACEUTICALS › Acetaminophen
  • 1931.6

Noradrenaline: fate and control of its biosynthesis.

Le Prix Nobel en 1970, 189-208., 1970.

Axelrod shared the Nobel Prize in Physiology or Medicine with Bernard Katz and Ulf von Euler in 1970 for his work on the release and reuptake of catecholamine neurotransmitters, a class of chemicals in the brain that include epinephrine, norepinephrine, and dopamine. He summarized this work in his Nobel Lecture.

Subjects: Neurophysiology, PHARMACOLOGY, PHARMACOLOGY › PHARMACEUTICALS › Cardiovascular Medications