CORBETT, Kizzmekia Shanta
Posted online on February 17, 2020. 2019-nCoV was an interim name for the Novel Coronavirus. These studies, which included the 3D structure of the RBD (receptor binding domain) within the S protein, provided information fundamental to the development of the mRNA vaccines for Covid-19.
"The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern. The virus binds to host cells through its trimeric spike glycoprotein, making this protein a key target for potential therapies and diagnostics. Wrapp et al. determined a 3.5-angstrom-resolution structure of the 2019-nCoV trimeric spike protein by cryo–electron microscopy. Using biophysical assays, the authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor. They also tested three antibodies known to bind to the SARS-CoV spike protein but did not detect binding to the 2019-nCoV spike protein. These studies provide valuable information to guide the development of medical counter-measures for 2019-nCoV." Order of authorship in the original publication: Wrapp, Wang, Corbett....Graham... Available from PubMedCentral at this link.
Subjects: BIOLOGY › MOLECULAR BIOLOGY, IMMUNOLOGY › Vaccines, INFECTIOUS DISEASE › SARS CoV-2 (Cause of COVID-19), VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)