An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: April 29, 2024


1 entries
  • 10006

Composition of tubular fluid in the macula densa segment as a factor regulating the function of the juxtaglomerular apparatus.

Circulation Research, 21 (Suppl.2) 79-90, 1967.

"This demonstration of 'tubulo-glomerular feedback' therefore provided mechanistic insights into one of the fundamental homeostatic functions of the kidney—the ability to conserve salt and water. Adjusting filtered sodium load to match tubular reabsorptive capacity is essential to prevent excessive urinary sodium losses that would quickly result in cardiovascular collapse. Demonstration of this feedback loop between the tubular and glomerular portions of the same nepron provided a new dimension to understanding the nephron as a single, connected physiological unit" (Feehally et al, Landmark papers in nephrology [2013] 1.4, p. 9) With J. Schnermann, W. Nagel, M. Horster, and M. Wahl.

Subjects: NEPHROLOGY › Renal Physiology