An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

TANABE, Koji

1 entries
  • 14063

Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Cell, 131, 861-872, 2007.

Yamanaka (Nobel Prize 2012) and colleagues demonstrated the generation of Induced Pluripotent Stems Cells (iPS) from adult human dermal fibroblasts with the same 4 mice factors they used in GM 13287. By overexpressing these transcription factors in the human fibroblasts they report having isolated human pluripotent stems cells that resemble human embryonic stem cells by all measured criteria. At the end of their paper they stated, "Our study has opened an avenue to generate patient and disease-specific pluripotent stem cells."

Order of authorship in original publication: Takahashi, Tanabe, Ohnuki, Yamanaka.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › Cell Biology, Regenerative Medicine