An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to Circa 2020 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15475 entries, 13329 authors and 1903 subjects. Updated: December 3, 2021

HAYFLICK, Leonard

3 entries
  • 8381

The serial cultivation of human diploid cell strains.

Exp. Cell. Res., 25 (3), 585-621., 1961.

The Hayflick limit. Hayflick demonstrated that a population of normal human fetal cells in a cell culture will divide between 40 and 60 times. The population then enters a senescence phase. 



Subjects: BIOLOGY › Cell Biology, GERIATRICS / Gerontology / Aging
  • 3215.5

Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO.

Proc. nat. Acad. Sci. (Wash.), 48, 41-49, 1962.

A mycoplasma shown to be the cause of some cases of primary atypical pneumonia, or "walking pneumonia." With M. F. Barile.



Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Mycoplasma › Mycoplasma Pneumonia, INFECTIOUS DISEASE › Pneumonia, RESPIRATION › Respiratory Diseases
  • 8380

George A Sacher, Life table modification and life prolongation. IN: Handbook of the biology of aging, edited by Caleb E. Finch and Leonard Hayflick, pp. 582–638.

New York: Van Nostrand Reinhold, 1970.

"The building of a connection between the Gompertz equation and the biology of ageing owes much to the work of biophysicist George Sacher [10] of the Argonne National Laboratory, whose introduction to ageing stemmed from the growing recognition during the 1950s that irradiation would shorten length of life [11]. The same recognition led physicist Leo Szilard [12] to propose the somatic mutation theory of ageing and prompted a range of studies on the effects of radiation on ageing both in animal models such as Drosophila (e.g. [13]) and also in human survivors of atomic bomb irradiation [14].

Sacher [10] used the Gompertz model to compare the patterns of increase in age-specific mortality rates across different species. By plotting age-specific mortality on a logarithmic scale against age (figure 1), he showed that a linear increase was generally observed, in accordance with the logarithmic version of equation (1.1), i.e.Embedded Image   

"Thomas B. L. Kirkwood, Decipherng death: a commentary on Gompertz (1825) 'On the nature of the function express of the law of human mortality and on a new mode of determining the value of life contingencies"). (http://rstb.royalsocietypublishing.org/content/370/1666/20140379,  accessed 01-2017



Subjects: COMPUTING/MATHEMATICS in Medicine & Biology, DEMOGRAPHY / Population: Medical Statistics, GERIATRICS / Gerontology / Aging