Of the 71 editions of Cicero's classical work on aging and death printed in the 15th century, Cato major de senectute, the Incunabula Short Title Catalogue cites 71, indicating the extreme popularity of Cicero's works in the early years of printing. This is the earliest edition with a definite date, and this and two other editions that might have been printed slightly before 1469 represent some of the very first works with a medical aspect that were printed. ISTC ic00579500. Digital facsimile from the Bayerische Staatsbibliothek at this link.

First description of the "method of loci," the memory technique as known as the "memory palace." Because of its wide use during the Middle Ages this text survives in hundreds of medieval manuscripts. Fourteen printed editions appeared in the 15th century.

ISTC No. ic00672000 . Digital facsimile from the Bayerische Staatsbibliothek at this link.

This work was Banjamin Franklin's personal favorite of the works printed by him, and is one of the finest books to emanate from a Colonial American press. It was the first classical text printed in North America, and the translation was by Franklin's friend James Logan. The work's genesis was in in the winter of 1741-2, when a trial sheet was sent to Logan, but more pressing printing work (in particular, the many religious pamphlets of 1743-4) obtruded. With the arrival from London of David Hall, Franklin had leisure to complete the book, which went on sale in mid-March, 1744. It contains an introduction by Franklin entitled, "The printer to the reader." Digital facsimile from Google Books at this link.