An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

PTASHNE, Mark

1 entries
  • 13988

Specific binding of the λ phage repressor to λ DNA.

Nature, 214, 232-234, 1967.

Ptashne was the first to demonstrate specific binding between protein and DNA.  Abstract for the paper: "Genetic experiments show that a group of genes may be switched off by the product of a regulator gene, called a repressor. An isolated repressor is shown here to bind specifically and with high affinity to DNA, strongly suggesting that, in vivo, repressors block the transcription from DNA to RNA by binding directly to the DNA."



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids