An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15959 entries, 13943 authors and 1935 subjects. Updated: February 27, 2024

ROSE, Noel Richard

3 entries
  • 2578.20
  • 3855.3

Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit.

J. Immunol., 76, 408-16, 1956.

Autoimmune thyroiditis

  • 13471

Chronic thyroiditis and autoimmunization.

J. Am. Med. Assoc., 1645, 1439-47, 1957.

"Witebsky helped develop procedures for the isolation and partial characterization of A and B blood antigens. He also began the practice of neutralization of certain antibodies in the blood of universal blood donors.

"In 1957 he co-authored a paper the "Witebsky's postulates" which determined whether a disease entity could be regarded as an autoimmune disease:[4]

  • Direct demonstration of free circulating antibodies active at body temperature.
  • Recognition of the specific antigen (for this antibody).
  • Production of antibodies against same antigen in experimental animals.
  • Experimental animal demonstrates same tissue changes in human." (Wikipedia article on Ernst Witebsky, accessed 8-2021)

  • 13472

Defining criteria for autoimmune diseases (Witebsky's postulates revisited).

Immunol. Today, 14, 436-30, 1993.

In 1993 Rose and Bona revised Witebsky's postulates "based on direct evidence from transfer of pathogenic antibody or pathogenic T-cells, indirect evidence based on reproduction of the autoimmune disease in experimental animals and circumstantial evidence from clinical clues.:[5]

  • Auto-antibodies detectable in all cases of disease.
  • Experimentally reproducible by immunization with antigen.
  • Experimental disease must show immunopathological lesions that parallel those in the natural disease.
  • Transferable by serum or lymphoid cells." (Wikipedia article on Ernst Witebsky, accessed 8-2021).