The first genome sequence of a single human (Craig Venter), including analysis and comments on his genetic markers, and their possible medical and prognosticating implications. 
(Order of authorship in the original publication: Levy, Sutton, Ng....Venter).
It has been estimated that the cost of sequencing the first human genome using first generation machines may have reached $100 million. Within a year the costs of sequencing a genome declined substantially. James Watson's genome, the second human genome sequenced, was accomplished in 2008 at a cost of $1.5 million. 
(Thanks to Juan Weiss for this reference and its interpretation.)