An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

FRASER, Sir Thomas Richard

4 entries
  • 1866.1

On the physiological action of the Calabar bean (Physostigma venenosum, Balf).

Trans. roy. Soc. Edinb. (1866), 24, 715-88, 1867.

Isolation of eserine (physostigmine).

Subjects: PHARMACOLOGY › PHARMACEUTICALS › Botanic Sources of Single Component Drugs › Physostigma venenosum (Calabar Bean)
  • 1867

On the connection between chemical constitution and physiological action.

Trans. roy. Soc. Edinb. 25, 151-203, 693-739, 18681869.

Brown and Fraser were the first to investigate the relationship between the chemical constitution of substances and their action upon the body.

"Although Crum Brown apparently never contemplated the practice of medicine, his training as a medical student gave him an interest in physiology and pharmacology which led him to collaborate during 1867–8 with T. R. Fraser, a distinguished medical graduate a few years younger than himself, in a pioneering investigation of fundamental importance on the connection between chemical constitution and physiological action. Their method "consists in performing upon a substance a chemical operation which shall introduce a known change into its constitution, and then examining and comparing the physiological action of the substance before and after the change." The change considered was the addition of ethyl iodide to various alkaloids and comparison of the iodides (and the corresponding sulfates) thus obtained with the hydrochlorides of the original alkaloids. Striking regularities were observed, amongst others "that when a nitrile [tertiary] base possesses a strychnialike action, the salts of the corresponding ammonium [quaternary] bases have an action identical with curare [poison]."[6] (Wikipedia article on Alexander Crum Brown, accessed 4-2020).

Subjects: BIOCHEMISTRY, PHARMACOLOGY › Pharmacodynamics
  • 1885

Strophanthus hispidus; its natural history, chemistry, and pharmacology.

Trans. roy. Soc. Edinb., 35, 955-1027; 36, 343-457, 1890, 1892.

Introduction of Strophanthus hispidus.

Subjects: PHARMACOLOGY › PHARMACEUTICALS › Botanic Sources of Single Component Drugs › Strophanthus hispidus
  • 2108

On the rendering of animals immune against the venom of the cobra and other serpents; and on the antidotal properties of the blood serum of the immunised animals.

Brit. Med. J., 1, 1309-12, 1895.

Fraser investigated the possibilities of immunization against cobra venom and obtained “antivenene”, an antivenom serum.

Subjects: IMMUNOLOGY › Immunization, TOXICOLOGY › Venoms