An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16018 entries, 14076 authors and 1941 subjects. Updated: July 14, 2024

KÜHNE, Wilhelm Friedrich

7 entries
  • 620

Untersuchungen über Bewegungen und Veränderungen der contraktilen Substanz.

Arch. Anat. Physiol, wiss. Med., 564-642, 748-835, 1859.

Proof of the coagulability of muscle proteins.



Subjects: BIOCHEMISTRY
  • 1269

Ueber die peripherischen Endorgane der motorischen Nerven.

Leipzig: Wilhelm Engelmann, 1862.

Kühne described the neuromuscular end organ (“Kühne’s spindle”) and introduced the term “telolemma” for the outer covering of its sheath.



Subjects: NEUROSCIENCE › NERVOUS SYSTEM › Peripheral Nerves / Nerve Impulses
  • 1270

Die Muskelspindeln. Ein Beitrag zur Lehre von der Entwickelung der Muskeln und Nervenfasem.

Virchows Arch. path. Anat., 28, 528-38, 1863.

The best early description of proprioceptive receptors in muscles.



Subjects: NEUROSCIENCE › NERVOUS SYSTEM › Peripheral Nerves / Nerve Impulses
  • 1012

Ueber das Trypsin.

Verh. naturh.-med. Ver. Heidelberg, n.F. 1, 194-98, 18741877.

Isolation of trypsin.



Subjects: GASTROENTEROLOGY › Anatomy & Physiology of Digestion
  • 700.1

Ueber das Verhalten verschiedener organisirter und sog. ungeformter Fermente (pp.191-193); Trypsin (Enzym des Pankreas) (pp.194-198).

Verh. Naturhist.-Med. Ver., NF, 1/3, 191-198, 1876.

Kühne was one of the people who introduced the term “enzyme”. He wrote, "Um Missverständnisse vorzubeugen und lästige Umschreibungen zu vermeiden schlägt Vortragender vor, die ungeformten oder nicht organisierten Fermente, deren Wirkung ohne Anwesenheit von Organismen und ausserhalb derselben erfolgen kann, als Enzyme zu bezeichnen..." (p.190). [In order to avoid misunderstandings and tiresome paraphrases, the lecturer proposes to call the unformed or unorganized ferments, whose action can take place without the presence of organisms and outside them, enzymes....]



Subjects: BIOCHEMISTRY, Zymology (Zymurgy) (Fermentation)
  • 1519

Ueber den Sehpurpur.

Untersuch. physiol. Inst. Univ. Heidelberg, 1, 15-103, 1878.

Kühne was Professor of Physiology at Amsterdam and Heidelberg. Among his best work is his investigation of visual purple (rhodopsin) which he was first to extract from the retina. Several other papers by him on the same subject appear in the above volume.



Subjects: OPHTHALMOLOGY › Physiology of Vision
  • 1016

Ueber die nächsten Spaltungsproducte der Eiweisskörper.

Z. Biol., 19, 159-208, 1883.

Kühne and Chittenden isolated and named several new substances during their investigation of the products of digestion. See also the same journal, 1884, 20, 11-51; 1886, 22, 409-58; 1889, 25, 358-67.



Subjects: GASTROENTEROLOGY › Anatomy & Physiology of Digestion