An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16031 entries, 14098 authors and 1944 subjects. Updated: October 9, 2024

CASTLE, William Bosworth

2 entries
  • 3143

Observations on the etiologic relationship of achylia gastrica to pernicious anemia. I. The effect of the administration to patients with pernicious anemia of the contents of the normal human stomach recovered after the ingestion of beef muscle.

Amer. J. med. Sci., 178, 748-64, 1929.

Castle showed pernicious anemia to be due to absence from the gastric juice of a substance (Castle’s intrinsic factor, hemopoietin) that reacts with an extrinsic factor present in many foodstuffs to form the anti-pernicious anemia factor. His experimental work resulted in the introduction of stomach preparations for the treatment of pernicious anemia. Preliminary communication in J. Clin. Invest., 1928, 6, 2.



Subjects: HEMATOLOGY › Anemia & Chlorosis
  • 3145.1

Intravenous use of extract of liver.

J. Amer. Med. Assoc., 96, 1198-1201, 1931.


Subjects: HEMATOLOGY › Anemia & Chlorosis, HEPATOLOGY › Hepatic Physiology