An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15959 entries, 13943 authors and 1935 subjects. Updated: February 27, 2024

ZHANG, Yong-Zhen (Zhang Yongzhen)

2 entries
  • 12119

A new coronavirus associated with human respiratory disease in China.

Nature, 579, 265-269, 2020.

Order of authorship in the original publication: Wu, Zhao...Holmes, Zang. This was the first paper written in China, and published in a Western language, on the first COVID-19 patient admitted to any Wuhan hospital on December 26, 2019. Nature received the paper on January 7, 2020, but did not publish it until February 3, 2020.


"Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1,2,3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here ‘WH-Human 1’ coronavirus (and has also been referred to as ‘2019-nCoV’). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China5. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans."

Open access from at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: COUNTRIES, CONTINENTS AND REGIONS › China, People's Republic of, EPIDEMIOLOGY › Pandemics › COVID-19, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)
  • 13485

Novel 2019 coronavirus genome.


"Novel 2019 coronavirus genome

"10th January 2020

"This posting is communicated by Edward C. Holmes, University of Sydney on behalf of the consortium led by Professor Yong-Zhen Zhang, Fudan University, Shanghai

"The Shanghai Public Health Clinical Center & School of Public Health, in collaboration with the Central Hospital of Wuhan, Huazhong University of Science and Technology, the Wuhan Center for Disease Control and Prevention, the National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control, and the University of Sydney, Sydney, Australia is releasing a coronavirus genome from a case of a respiratory disease from the Wuhan outbreak. The sequence has also been deposited on GenBank (accession MN908947 31.5k) and will be released as soon as possible.

"Update: This genome is now available on GenBank and an updated version has been posted 31.5k.

Please feel free to download, share, use, and analyze this data. We ask that you communicate with us if you wish to publish results that use these data in a journal. If you have any other questions –then please also contact us directly.

"Professor Yong-Zhen Zhang,
Shanghai Public Health Clinical Center & School of Public Health,
Fudan University."

(Thanks to Juan Weiss for this reference.)

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics, DIGITAL RESOURCES, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)