TISELIUS, Arne Wilhelm Kaurin
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The moving boundary method of studying the electrophoresis of proteins. (Nova Acta Reg. Soc. Scient. Upsaliensis, IV, 7, No. 4.)Uppsala, Sweden: Almqvist & Wiksell, 1930.Tilesius's doctoral dissertation introduced the laboratory technique of moving-boundary electrophoresis, a technique for separation of chemical compounds by electrophoresis in free solution. Subjects: BIOCHEMISTRY, Laboratory Medicine, NOBEL PRIZES › Nobel Prize in Chemistry |
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A new apparatus for electrophoretic analysis of colloidal mixtures.Trans. Faraday Soc., 33, 524-531, 1937.Between 1931 and 1937, with financial support from the Rockefeller Foundation, Tiselius developed his "Tiselius apparatus" for moving boundary electrophoresis. In this paper he demonstrated that electrophoresis separated protein fractions into four bands that he named: 1) albumin, 2) alpha, 3) beta, 4) gamma. Subjects: BIOCHEMISTRY, Laboratory Medicine |
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Electrophoresis of serum globulin. II- Electrophoretic analysis of normal and immune sera.Biochemical Journal, 31, 1464-1477, 1937.Tiselius showed that an antibody that he produced in a rabbit by immunizing it with albumin (ovalbumin) was clearly located in the gamma globulin fraction. He summarized the paper with this statement: "Investigation of a highly potent anti-egg albumin ('ovalbumin') serum from rabbit showed that the antibody function migrated with the gamma globulin fraction only." Subjects: BIOCHEMISTRY, IMMUNOLOGY, Laboratory Medicine |
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An electrophoretic study of immune sera and purified antibody preparations.J. exp. Med., 69, 119-31, 1939.Antibodies shown to be gamma globulins. Subjects: IMMUNOLOGY › Immunization |