An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15849 entries, 13787 authors and 1925 subjects. Updated: January 28, 2023

BLUMBERG, Baruch Samuel

4 entries
  • 3666.4

A “new” antigen in leukemia sera.

J. Amer. med. Assoc., 191, 541-46, 1965.

(Order of authorship in the original publication: Blumberg, Alter, Visnich.) Discovery of Australia antigen, hepatitis B antigen, Aa, later called HBsAg.  Blumberg received half of the Nobel Prize for Medicine in Biology in 1976 for the discovery of the antigen, for discovery of the hepatitis B virus, and for the discovery/ invention of the hepatitis B vaccine— the first cancer vaccine.  See B. S. Blumberg, Hepatitis B: The Hunt for a Killer Virus (Princeton: Princeton University Press, 2002.)



Subjects: HEPATOLOGY › Diseases of the Liver, IMMUNOLOGY › Immunization, INFECTIOUS DISEASE › Hepatitis, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis B Virus
  • 6840

Particles associated with Australia antigen in the sera of patients with leukemia, Down's syndrome and hepatitis.

Nature (Lond.), 218, 1057-1059, 1968.

Particles with the appearance of a virus were detected by electron microscopy in the serum of individuals with Au. These were subsequently shown to be the surface antigen particles, different from the whole virus particles. Blumberg's discovery of the Australia antigen in 1965 may technically be considered the discovery of the hepatitis B virus, but at the time of that discovery its connection with a virus was speculative. 

 



Subjects: INFECTIOUS DISEASE › Hepatitis, ONCOLOGY & CANCER › Leukemia, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis B Virus
  • 6841

Vaccine against viral hepatitis and process. Serial No. 864,788 filed 10 /8 /[19]69. Patent 3636191 issued 1/ 18/ [19]72.

Washington, DC: U.S. Patent Office, 19691972.

First description of the hepatitis B vaccine, the first cancer vaccine, US patent 3636191A. Millman and Blumberg discovered that the blood of individuals carrying the hepatitis B virus contained particles of the outside coating of the virus. This coating, hepatitis B surface antigen (HBsAg), is not infectious; however, HBsAg can provoke an immune response. To develop a vaccine, Millman and Blumberg invented a method of detaching the coatings from the virus. See B. S. Blumberg, editor, Hepatitis B and the Prevention of Primary Cancer of the Liver. Selected Publications of Baruch S. Blumberg. (2000). See also I. Millman, T. Eisenstein & B. Blumberg, Hepatitis B: The Virus, the Disease, and the Vaccine. (New York: Plenum Press, 1984). 



Subjects: HEPATOLOGY › Diseases of the Liver, IMMUNOLOGY › Immunization, IMMUNOLOGY › Vaccines, INFECTIOUS DISEASE › Hepatitis, LAW and Medicine & the Life Sciences › Medical Patents, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis B Virus
  • 12321

Australia antigen (a hepatitis-associated antigen). Purification and physical properties.

J. exp. Med., 131, 1190-1199, 1970.

 Purification of the Australia antigen and investigation of its physical properties. (Order of authorship in the original publication: Millman, Loeb, Bayer, Blumberg.)



Subjects: INFECTIOUS DISEASE › Hepatitis, VIROLOGY › VIRUSES (by Family) › Hepadnaviridae › Hepatitis B Virus