An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15849 entries, 13787 authors and 1925 subjects. Updated: January 28, 2023

BEST, Charles Herbert

5 entries
  • 1205
  • 3967

The internal secretion of the pancreas.

J. Lab. clin. Med., 7, 251-66, 19211922.

This paper reports the isolation of insulin. An extract from the pancreas of a dog, removed after ligation of the excretory duct, was found to exercise a reducing influence on the percentage of sugar in the blood. Digital facsimile from insulin.library.utoronto.ca at this link.



Subjects: Ductless Glands: Internal Secretion › Pancreas, HEPATOLOGY, Metabolism & Metabolic Disorders › Diabetes
  • 3966

The internal secretion of the pancreas. (Abstract).

Amer. J. Physiol., 59, 479, 1922.

A preliminary one-page communication regarding the isolation of insulin, made to a meeting of the American Physiological Society in December 1921. Banting and Macleod were awarded the Nobel Prize in 1923. Banting was only 32 years old at the time. When I wrote this note in 2017 Banting remained the youngest person to every receive the Nobel Prize for physiology or medicine. Digital facsimile from insulin.library.utoronto.ca at this link.



Subjects: Metabolism & Metabolic Disorders › Diabetes
  • 3968

Pancreatic extracts in the treatment of diabetes mellitus.

Canad. med. Ass. J., 12, 141-46, 1922.

The first clinical application of insulin in the treatment of diabetes. Co-authored by W. R. Campbell, and A. A. Fletcher. Digital facsimile from PubMedCentral at this link.



Subjects: Metabolism & Metabolic Disorders › Diabetes
  • 1916

The nature of the vaso-dilator constituents of certain tissue extracts.

J. Physiol. (Camb.), 62, 397-417, 1927.

Proof that histamine occurs in certain organs in amounts sufficient to account for the depressant action of extracts of these organs. With H. H. Dale, H. W. Dudley, and W. V. Thorpe.



Subjects: PHARMACOLOGY › PHARMACEUTICALS › Cardiovascular Medications
  • 3019

Heparin and the thrombosis of veins following injury.

Surgery, 2, 163-87, 1937.

Order of authorship in the original publication: Murray, Jaques, Perrett, Best. Heparin was discovered by Jay McLean and William Henry Howell in 1916; however it was not tested as an anticoagulant in clinical trials until 1935.  With L.B. Jaques, T. S. Perrett.



Subjects: HEMATOLOGY › Anticoagulation, VASCULAR SURGERY