MURAD, Ferid
1 entries
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Nitric oxide activates guanylate cyclase and increases guanosine 3',5'-monophosphate levels in various tissue preparations.Proc. Nat. Acad. Sci. (U.S.A.), 74, 3203-3207, 1977.Murad demonstrated that nitroglycerin and related drugs worked by releasing nitric oxide into the body, which relaxed smooth muscle by elevating intracellular cyclic GMP. With Subjects: CARDIOLOGY › CARDIOVASCULAR PHYSIOLOGY, NOBEL PRIZES › Nobel Prize in Physiology or Medicine |