An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15826 entries, 13745 authors and 1921 subjects. Updated: December 1, 2022

JACOB, François

5 entries
  • 13994

Induction spontanée du développement du bactériophage lambda au cours de la recombinaison génétique, chez Escherichia coli K 12.

Compt. Rend. Acad. Sci., 239, 317-319, 1954.

Wollman and Jacob discovered zygotic induction. This occurs when a bacterial cell carrying the silenced DNA of a bacteriophage transfers the viral DNA along with its own DNA in its chromosome to another bacterial cell lacking the virus, causing the recipient of the DNA to break open. In the donor cell, a repressor protein encoded by the prophage (viral DNA) keeps the viral genes turned off so that virus is not produced. When DNA is transferred to the recipient cell by conjugation, the viral genes in the transferred DNA are immediately turned on because the recipient cell lacks the repressor. As a result, many viruses are made in the recipient cell, and lysis eventually occurs to release the new virus.... Zygotic induction provided insight into the nature of bacterial conjugation. It also contributed to the development of the early repression model of gene regulation that explained how the lac operon and λ bacteriophage genes are negatively regulated.

  • 6894

Sur l’expression et le rôle des allèles “inductible” et “constitutif” dans la synthèse de la β-galactosidase chez des zygotes d’ “Escherichia coli.

C. R. Acad. Sci. (Paris), 246, 3125-3128, 1958.

The “PaJaMo” experiment of PArdee, JAcob, and MOnod “broke the impasse in Crick and Brenner’s comprehension of how information in the sequence of bases in DNA came to be expressed as a sequence of the amino acids in protein, and thus led to the theory of the messenger and the solution of the coding problem” (Judson 390).

This was recorded definitively in “The Genetic Control and Cytoplasmic Expression of ‘Inducibility’ in the Synthesis of β-galactosidase by E. coli,” J. Mol. Biol. 1 (1959) 165-78.

Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis
  • 13995

L'opéron: Groupe de gènes à expression coordonnée par un opérateur.

Compt. rend. l'Acad. Sci., 250, 1727-1729, 1960.

Jacob and Monod received their share of the Nobel Prize in 1965 for their discoveries concerning the operon and viral synthesis. The first operon they described was the lac operon in E. coli. Their operon theory suggested that in all cases, genes within an operon are negatively controlled by a repressor acting at a single operator located before the first gene. Later, it was discovered that genes could be positively regulated, and also regulated at steps that follow transcription initiation. Therefore, no generalized regulatory mechanism is possible because different operons have different mechanisms. Today, an operon is defined as a functioning unit of DNA containing a cluster of genes under the control of a single promotor, transcribed together into a single mRNA strand. 

  • 256.9

Genetic regulatory mechanisms in the synthesis of proteins.

J. molec. Biol., 3, 318-56, 1961.

Jacob, Monod, and André Lwoff shared the Nobel Prize in 1965 for their discovery of a gene whose function is to regulate the activity of other genes.

  • 256.10

An unstable intermediate carrying information from genes to ribosomes for protein synthesis.

Nature, 190, 576-80, 1961.

Demonstration of the existence of “messenger” RNA. The following paper (pp. 581-85) by F. Gros et al. is also relevant.