An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16032 entries, 14099 authors and 1944 subjects. Updated: October 19, 2024

MELDAL, Morten Peter

1 entries
  • 14292

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides.

J. Organic Chemistry, 67, 3057-3064, 2002.

In 2022 Morten Meldal shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Barry Sharpless for the discovery of click chemistry. Simultaneously, but independently of Sharpless, the authors discovered that copper substantially catalyzes
the cycloaddition reaction between azides and terminal alkynes. The efficiency of this reaction, combined with robustness and ease of operation, quickly made this the "go to" for transformations this sort. This reaction became the very epitome of click chemistry.

Order of authorship in the original publication: Tornoe, Christensen, Meldal.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: Chemistry, NOBEL PRIZES › Nobel Prize in Chemistry