An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15957 entries, 13939 authors and 1935 subjects. Updated: February 16, 2024

STEINMETZ, Nicole F.

1 entries
  • 13484

COVID-19 vaccine development and a potential nanomaterial path forward.

Nature Nanotechology, 15, 646-655, 2020.

Published 15 July 2020. Order of authorship in original publication: Shin, Shukla, Chung....Steinmetz. Probably the first publication on the type of nanotechnology involved in production of the Moderna and Pfizer mRNA vaccines for Covid-19 — vaccines developed within unprecedented short periods of time and manufactured on unprecedented scale.

"Abstract

"The COVID-19 pandemic has infected millions of people with no clear signs of abatement owing to the high prevalence, long incubation period and lack of established treatments or vaccines. Vaccines are the most promising solution to mitigate new viral strains. The genome sequence and protein structure of the 2019-novel coronavirus (nCoV or SARS-CoV-2) were made available in record time, allowing the development of inactivated or attenuated viral vaccines along with subunit vaccines for prophylaxis and treatment. Nanotechnology benefits modern vaccine design since nanomaterials are ideal for antigen delivery, as adjuvants, and as mimics of viral structures. In fact, the first vaccine candidate launched into clinical trials is an mRNA vaccine delivered via lipid nanoparticles. To eradicate pandemics, present and future, a successful vaccine platform must enable rapid discovery, scalable manufacturing and global distribution. Here, we review current approaches to COVID-19 vaccine development and highlight the role of nanotechnology and advanced manufacturing."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: IMMUNOLOGY › Immunization, IMMUNOLOGY › Vaccines, INFECTIOUS DISEASE › SARS CoV-2 (Cause of COVID-19), Nanotechnology in Medicine, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)