An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

ZAMECNIK, Paul Charles

1 entries
  • 13969

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).

Proc. Nat. Acad. Sci. (USA), 75, 280-284, 1978.

Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell culture. This work on gene expression modulation led to antisense therapy, or antisense therapeutics. Digital facsimile from PubMedCentral at this link.
Followed in the same journal issue by Zamecnik and Stephenson, "Inhibition of Rous viral RNA translation by a specific oligodeoxyribonucleotide (in vitro protein synthesis / nucleic acid hybridization / DNA nucleotidyltransferase)," Proc. Nat. Acad. Sci. (USA), 75, 285-288. Digital facsimile from pnas.org at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, Biotechnology, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)