An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16271

  • 13969

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon).

Proc. Nat. Acad. Sci. (USA), 75, 280-284, 1978.

Zamecnick and Stephenson reported the first example of specific inhibition of gene expression by an oligonucleotide when they demonstrated that a short oligonucleotide inhibited Rous sarcoma virus replication in cell culture. This work on gene expression modulation led to antisense therapy, or antisense therapeutics. Digital facsimile from PubMedCentral at this link.
Followed in the same journal issue by Zamecnik and Stephenson, "Inhibition of Rous viral RNA translation by a specific oligodeoxyribonucleotide (in vitro protein synthesis / nucleic acid hybridization / DNA nucleotidyltransferase)," Proc. Nat. Acad. Sci. (USA), 75, 285-288. Digital facsimile from pnas.org at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Synthesis, Biotechnology, VIROLOGY › VIRUSES (by Family) › Retroviridae › Rous Sarcoma Virus (RSV)
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