FLEMING, Sir Alexander
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On a remarkable bacteriolytic element found in secretions and tissues.Proc. roy. Soc. B., 93, 306-17, 1922.Lysozyme, an antimicrobial enzyme that is a component of secretions such as tears and saliva. Subjects: BACTERIOLOGY, DENTISTRY › Dental Anatomy & Physiology, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics, PHARMACOLOGY › PHARMACEUTICALS › Antiviral Drugs |
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On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.Brit. J. exp. Path., 10, 226-36, 1929.Discovery of the growth-inhibiting action of Penicillium on certain bacteria. Subjects: Mycology, Medical, NOBEL PRIZES › Nobel Prize in Physiology or Medicine , PHARMACOLOGY › PHARMACEUTICALS › Antibiotics, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin |
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On the specific antibacterial properties of penicillin and potassium tellurite. Incorporating a method of demonstrating some bacterial antagonisms.J. Path. Bact., 35, 831-842, 1932.In this paper Fleming first described the use of penicillin as an antibacterial agent in man, and reported on experiments using it as a wound dressing for septic wounds. He also corrected the species name from Penicillium rubrum (1929) to Penicillium notatum. (Thanks to Juan Weiss for this reference and its interpretation.) Subjects: BACTERIOLOGY, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin, SURGERY: General › Wound Healing |
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Micro-methods of estimating penicillin blood serum and other bodily fluids.Lancet, 244, 620-621, 1944.Fleming was the first to measure blood levels of penicillin after intramuscular, intradermal, inravenous and continuous drip administration in order to determine the correct dosage. He described his micro-measurement methods in this paper. Subjects: PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin |
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Penicillin content of blood serum after various doses of penicillin by various routes.Lancet, 244, 621-624, 1944.In this paper Fleming and colleagues explained how to choose routes of administration of penicillin as well as dosage, and reproduced the graphs/figures that showed blood levels achieved with different doses and routes of administration. Subjects: ANESTHESIA, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin |
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Penicillin: Its practical application. Edited by Sir Alexander Fleming.London: Butterworths, 1946.This was the only book that Fleming ever published on penicillin. American issue, Philadelphia: Blakiston, 1946. Subjects: PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin |