An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #14839

  • 12599

Penicillin content of blood serum after various doses of penicillin by various routes.

Lancet, 244, 621-624, 1944.

In this paper Fleming and colleagues explained how to choose routes of administration of penicillin as well as dosage, and reproduced the graphs/figures that showed blood levels achieved with different doses and routes of administration.
Fleming was the first to use Procaine mixed with penicillin in order to alleviate the tremendous intramuscular pain of the injections. He showed that the anesthetic did not affect the bacterial killing power of the antibiotic. With M. Y. Young, A. J. E. Rowe.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: ANESTHESIA, PHARMACOLOGY › PHARMACEUTICALS › Antibiotics › Penicillin
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