An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15858 entries, 13798 authors and 1925 subjects. Updated: February 4, 2023

MEDAWAR, Sir Peter Brian

5 entries
  • 2578.4

The fate of skin homografts in man.

J. Anat. (Lond), 77, 299-310, 1943.

Gibson and Medawar placed the laws of transplantation on a firm scientific basis. A later paper by Medawar (J. Anat. [Lond.], 1944, 78, 176- 99) demonstrated that the mechanism of rejection of transplanted tissues is immunological in character.



Subjects: IMMUNOLOGY, TRANSPLANTATION, TRANSPLANTATION › Skin Grafting
  • 13595

The technique of free skin grafting in mammals.

J. Exp. Biol., 28, 385-402, 1951.

This "paper facilitated the later discovery of `actively acquired tolerance' and the definition of the principal laws of transplantation tolerance. Fittingly, this line of experimentation led to the awarding of the 1960 Nobel Prize in Physiology and Medicine to Medawar. Thus, it was in a series of classic experiments (stemming from this J. Exp. Biol. paper) that the field of transplantation biology was born....
This "paper is a self-contained manual for distinct forms of skin transplants in a variety of laboratory animals. There are very detailed discussions and illustrations concerning the anatomy of the mammalian integument. Importantly, the paper also provides unique information on regional variation of skin within a given animal and on the process of transplant survival or rejection. Specific discussions focus on principles of wound healing post-transplantation and on Billingham and Medawar's formative thoughts on transplantation immunity. The paper is most useful in discussing frankly the pros and cons of skin grafting as a laboratory procedure. There is considerable discussion of the pitfalls encountered in skin grafting, e.g. pigmentation and hair growth, but also the advantages, e.g. accessibility and availability for biopsy" (Santa Jeremy Ono, "The birth of transplantation immunology: The Billingham-Medawar Experiments at Birmingham University and University College London" (J. Exp. Biol, 207 (2004) 4013-4014).

Digital facsimile of the 1951 paper from cob.silverchair-cdn.com at this link.



Subjects: IMMUNOLOGY, TRANSPLANTATION, TRANSPLANTATION › Skin Grafting
  • 2578.11

‘Actively acquired tolerance’ of foreign cells.

Nature (Lond.), 172, 603- 06, 1953.

Proof of Burnet and Fenner’s theory of immunity. For their discovery of acquired immunological tolerance Medawar and Burnet (No. 2578.7) shared the Nobel Prize in 1960.



Subjects: IMMUNOLOGY › Immunization
  • 2578.12

Quantitative studies on tissue transplantation immunity. I. The survival times of skin homografts exchanged between members of different inbred strains of mice. II. The origin, strength and duration of actively and adoptively acquired immunity.

Proc. roy. Soc. B, 143, 43-80, 1954.

Experimental production of immunological tolerance by Billingham and colleagues.Paper II distinguished adoptive from passive immunization. E. M. Sparrow was a co-author of paper I.



Subjects: IMMUNOLOGY › Immunization, TRANSPLANTATION, TRANSPLANTATION › Skin Grafting
  • 2578.24

The homograft reaction.

Proc. roy. Soc. B, 149, 145-66, 1958.

Medawar showed grafting to be unsuccessful when donor and recipient animals came from the same litter, unless the two are genetically identical – another instance of the delayed hypersensitivity reaction.



Subjects: IMMUNOLOGY › Immunization