1932 KIKUTH, Walter (1896 – 1968)

Zur Weiterentwicklung synthetisch dargestellter Malariamittel. I. Ueber die chemotherapeutische Wirkung des Atebrin.

Introduction of atebrin (mepacrine, quinacrine).

GMN 5257 · https://historyofmedicine.com/id/7919

1934 TATUM, Arthur Lawrie (1884 – 1955); COOPER, Garrett Arthur (1904 – )

An experimental study of mapharsen (meta-amino para-hydroxy phenyl arsine oxide) as an antisyphilitic agent.

Introduction of mapharsen.

GMN 2415 · https://historyofmedicine.com/id/3412

1937 LEVADITI, Constantin (1874 – 1953); VAISMAN, A

La toxi-infection gonococcique expérimentale et son traitement chimiothérapique.

Levaditi and Vaisman showed that sulfanilamide protected mice against gonococcal infection.

GMN 5213.1 · https://historyofmedicine.com/id/7817

1937 DEES, John Essary (1910 – 1993); COLSTON, John Archibald Campbell (1886 – 1971)

The use of sulfanilamide in gonococcic infections. Preliminary report.

GMN 5214.1 · https://historyofmedicine.com/id/7818

1938 BUTTLE, Gladwin Albert Hurst (1899 – 1983); ET AL

The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice.

G. A. H. Buttle, T. Dewing, G. E. Foster, W. H. Gray, S. Smith, and D. Stephenson discovered the potency of dapsone (DDS).

GMN 1926 · https://historyofmedicine.com/id/2722

1938 WHITBY, Sir Lionel Ernest Howard (1895 – 1956)

Chemotherapy of pneumococcal and other infections with 2-(p-aminobenzenesulphonamido) pyridine.

Experimental proof of the efficacy of sulfapyridine (M & B 693) in pneumococcal pneumonia.

GMN 1951 · https://historyofmedicine.com/id/2827

1938 GAISFORD, Wilfrid Fletcher (1902 – 1988); EVANS, Gladys Mary (1897 – 1973)

Treatment of pneumonia with 2-(p-aminobenzenesulphonamido) pyridine.

Clinical proof of the value of sulphapyridine. M & B 693 (sulphapyridine) treatment of pneumonia. This followed the experimental work of L. E. H. Whitby (see No. 1951).

GMN 1952 · https://historyofmedicine.com/id/2829

1943 FAGET, Guy Henry (1891 – 1947); ET AL

The promin treatment of leprosy. A progress report.

Promin (sodium glucosulphone) introduced in the treatment of leprosy. With R. C. Pogge, F. A. Johansen, J. F. Dinan, B. M. Prejean, and C. G. Eccles.

GMN 2441 · https://historyofmedicine.com/id/2921

1943 MAHONEY, John Friend (1889 – 1957); ARNOLD, Richard C. (1906 – 1992); HARRIS, Ad

Penicillin treatment of early syphilis. A preliminary report.

Mahoney and colleagues introduced penicillin in treatment of syphilis. This was the report of the first four cases of patients with early stages of the disease. Digital facsimile of the version published in the the Am…

GMN 2418 · https://historyofmedicine.com/id/3422

1943 HERRELL, Wallace Edgar (1909 – 1992); ET AL

Use of penicillin in sulfonamide resistant gonorrheal infections.

With E. N. Cook and L. Thompson.

GMN 5214.1 · https://historyofmedicine.com/id/7820

1944 ROSENBERG, David Harry (1903 – ); ARLING, Philip Arthur (1908 – 1955)

Penicillin in the treatment of meningitis.

GMN 4689.1 · https://historyofmedicine.com/id/970

1944 MUIR, Ernest (1880 – 1974)

Preliminary report on diasone in the treatment of leprosy.

Muir found diasone (a sulphone) valuable in the treatment of leprosy.

GMN 2442 · https://historyofmedicine.com/id/2923

1945 FELDMAN, William Hugh (1892 – 1974); HINSHAW, Horton Corwin (1902 – 2001)

Streptomycin in treatment of clinical tuberculosis: a preliminary report.

GMN 2350 · https://historyofmedicine.com/id/3125

1945 CURD, Francis Henry Swinton (1909 – 1948); ET AL

Studies on synthetic antimalarial drugs.

F. H. S. Curd, D. G. Davey, and F. L. Rose synthesized proguanil (“paludrine”) and first tested it in avian malaria.

GMN 5260 · https://historyofmedicine.com/id/8545

1945 ADAMS, Alfred Robert Davies (1901 – 1992)

Studies on synthetic antimalarial drugs. XIII. Results of a preliminary investigation of the therapeutic action of 4888 (paludrine) on acute attacks of benign tertian malaria.

First use of proguanil in human malaria. With B. G. Maegraith, J. D. King, R. H. Townsend, T. H. Davey, and R. E. Havard.

GMN 5261 · https://historyofmedicine.com/id/8546

1946 DOMAGK, Gerhard Johannes Paul (1895 – 1964); ET AL

Ueber eine neue, gegen Tuberkelbazillen in vitro wirksame Verbindungsklasse.

Introduction of thiosemicarbazone in treatment of tuberculosis. With R. Behnisch, F. Mietzsch, and H. Schmidt.

GMN 2351 · https://historyofmedicine.com/id/3129

1946 HART, Philip Montagu D'Arcy (1900 – 2006)

Chemotherapy of tuberculosis. Researches during the past 100 years.

GMN 2359 · https://historyofmedicine.com/id/3167

1946 MOST, Harry (1907 – 1994); LONDON, Irving M. (1918 – 2018); LAVIETES, Paul Harold (1907 – 1990)

Chloroquine for treatment of acute attacks of vivax malaria.

Harry Most led the development of chloroquine for use in treating American troops suffering from malaria. At the beginning of the American involvement in the war there were more American casualties from malaria than f…

GMN 5261.1 · https://historyofmedicine.com/id/8547

1947 VAN HOOF, L.

Sur la chimiothérapie de l’onchocercose. (Note préliminaire).

First effective chemotherapy (suramin) for onchocerciasis. With C. Heurard, E. Peel, and M. Wanson.

GMN 5351.4 · https://historyofmedicine.com/id/6887

1947 SMADEL, Joseph Edwin (1907 – 1963); JACKSON, Elizabeth B.

Chloromycetin, an antibiotic with chemotherapeutic activity in experimental rickettsial and viral infections.

Introduction of chloramphenicol, used in treatment of typhus.

GMN 1940 · https://historyofmedicine.com/id/8617

1948 HARKNESS, Arthur Herbert (1889 – 1970); BROWNLEE, G

Leprosy treated with sulphetrone in 1943.

Clinical use of solapsone (sulphetrone).

GMN 2442.1 · https://historyofmedicine.com/id/2925

1948 ALVING, Alf Sven (1902 – 1965)

Pentaquine (Sn-13,276), a therapeutic agent effective in reducing the relapse rate in vivax malaria.

Clinical trials of pentaquine. With B. Craige, R. Jones, C. M. Whorton, T. N. Pullman, and L. Eichelberger.

GMN 5261.2 · https://historyofmedicine.com/id/8548

1950 EDGCOMB, John Harold (1924 – 2007); ET AL

Primaquine, S.N. 13,272, a new curative agent in vivax malaria: a preliminary report.

Introduction of primaquine.

GMN 5262.3 · https://historyofmedicine.com/id/8552

1951 FALCO, E. A.

2:4-Diaminopyrimidines – a new series of antimalarials.

Preparation and laboratory tests of pyrimethamine. With L. G. Goodwin, G. H. Hutchings, I. M. Rollo, and P. B. Russell.

GMN 5262.4 · https://historyofmedicine.com/id/8553

1951 ROLLO, Ian McIntosh (1926 – 2015)

A 2:4-diamino pyrimidine in the treatment of proguanil-resistant laboratory malarial strains.

Pyrimethamine (daraprim).

GMN 5262.5 · https://historyofmedicine.com/id/8554

1952 ROBITZEK, Edward Heinrich (1912 – 1984); ET AL

Chemotherapy of human tuberculosis with hydrazine derivatives of isonicotinic acid. (Preliminary report of representative cases.)

Introduction of isoniazid. With I. J. Selikoff and G. G. Omstein. See also Amer. Rev. Tuberc., 1952, 65, 257-442.

GMN 2353 · https://historyofmedicine.com/id/3139

1956 DAVEY, Thomas Frank (1908 – 1983); CURRIE, Gordon

Clinical trials of diphenyl thiourea compound SU 1906 (Ciba 1509E) in the treatment of leprosy. Progress during the first year.

Introduction of diphenylthiourea (thiambutosine) therapy.

GMN 2442.2 · https://historyofmedicine.com/id/2927

1959 DAVEY, Thomas Frank (1908 – 1983); HOGERZEIL, L. M.

Diethyl dithiolisophthalate in the treatment of leprosy (ETIP or “Etisul”); a progress report.

Ditophal (Etisul) in leprosy.

GMN 2442.3 · https://historyofmedicine.com/id/2932

1959 RIST, Noël (1906 – 1990); ET AL

Experiments on the antituberculous activity of alpha-ethyl-thioisonicotinamide.

Ethionamide. With F. Grumbach and D. Liberman.

GMN 2353.2 · https://historyofmedicine.com/id/3146

1961 THOMAS, J. P.; ET AL

A new synthetic compound with antituberculous activity in mice; ethambutol (dextro-2, 2’-(ethylenediimino)-di-l-butanol).

Ethambutol for the treatment of tuberculosis. With C. O. Baughn, R. G. Wilkinson and R. G. Shepherd.

GMN 2353.3 · https://historyofmedicine.com/id/3149

1964 LAMBERT, C. R.

Chemotherapy of experimental Schistosoma mansoni infections with a nitro-thiazole derivative, CIBA 32, 644-Ba.

Introduction of niridazole (Ambilhar).

GMN 5351.6 · https://historyofmedicine.com/id/6892

1968 CASH, Richard Alan (1941 – 2024); NALIN, David R. (1941 – ); ISLAM, Rafiqul; PHILLIPS, Robert Allan (1906 – 1976); ET AL

Oral maintenance therapy for cholera in adults.

Abstract: "An oral solution containing glucose, sodium chloride, sodium bicarbonate, and potassium chloride or citrate was used as maintenance therapy for acute cholera. In comparison with control patients who receive…

GMN 14303 · https://historyofmedicine.com/id/16628

1970 REES, Richard John William (1917 – 1998); ET AL

Experimental and clinical studies on rifampicin in treatment of leprosy.

With J. M. H. Pearson and M. F. R. Waters.

GMN 2442.5 · https://historyofmedicine.com/id/2936

1971 CASH, Richard Alan (1941 – 2024); NALIN, David R. (1941 – )

Oral or nasogastric maintenance therapy in pediatric cholera patients.

GMN 14304 · https://historyofmedicine.com/id/16629

1985 KARMALI, Mohamed A.; PETRIC, Martin; LIM, Corazon; ET AL

The association between idiopathic hemolytic uremic syndrome and infection by Verotoxin-producing Escherichia coli.

Order of authorship in the original publication: Karmali, Petric, Lim. The authors discovered that a hemolytic uremic syndrome, associated with E. coli 0157-H7 (first described in No. 11376), and which could not be cu…

GMN 11377 · https://historyofmedicine.com/id/13576

1986 YARCHOAN, Robert (1950 – ); WEINHOLD, Kent James; LYERLY, Herbert Kim; ET AL

Administration of 3'-Azido-3'-Deoxythmymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.

Order of authorship in the original publication: Yarchoan, Weinhold, Lyerly. The first antiviral AIDS drug, later named "Retrovir"/ Zidovudine/AZT. (Thanks to Juan Weiss for this reference and its interpretation.)

GMN 11106 · https://historyofmedicine.com/id/13302

2005 TAYLOR, Mark J.; MAKUNDE, Williams Holmes; MCGARRY, Helen F.; ET AL

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: A double blind randomized placebo-controlled trial.

Order of authorship in the original paper: Taylor, Makunde, McGarry.... The authors treated infection by the parasitic worm Wuchereria bancrofti, cause of elephantiasis (lymphatic filariasis), by killing the Wolbachia…

GMN 11193 · https://historyofmedicine.com/id/13390

2014 ELKINGTON, Bethany Gwen; SOEJARTO, Djala Djendoel; SYDARA, Kongmany

Ethnobotany of tuberculosis in Laos.

GMN 13213 · https://historyofmedicine.com/id/15476

2015 VESALIUS, Andreas (1514 – 1564); GARRISON, Daniel H.

Vesalius: The China Root epistle. A new translation and critical edition, edited and translated by Daniel H. Garrison, with added illustrations from the 1543 and 1555 De humani corporis fabrica.

GMN 13024 · https://historyofmedicine.com/id/15274

2020 BAUM, Alina; AJITHDOSS, Dharani K.; KYRATSOUS, Christos A.; ET AL

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.

The authors, working at Regeneron, showed that a cocktail of two potent neutralizing monoclonal antibodes reduced virus load in the airways and diminshed viral induced pathological sequelae when given both as a prophy…

GMN 13523 · https://historyofmedicine.com/id/15799

2021 WEINREICH, David. M.; SIVAPALASINGAM, Sumathi; NORTON, Thomas; ET AL

REGN-COV-2, a neutralizing antibody cocktail, in outpatients with Covid-19.

The authors showed that the Regeneron antibody cocktail has a low incidence of side effects and a profound and rapid effect on viral load, with most reduction occurring within 48 hours, even in patents with the highes…

GMN 13524 · https://historyofmedicine.com/id/15800

2021 OWEN, Dafydd R.; ALLERTON, Charlotte M. N.; ANDERSON, Annaliesa S.

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed …

GMN 14023 · https://historyofmedicine.com/id/16330