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Garrison-Morton-Norman History of Medicine

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80 entries match Diabetes [C19.246]

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1922

#3968

Pancreatic extracts in the treatment of diabetes mellitus.

COLLIP, James Bertram (1892 – 1965)
COLLIP, James Bertram (1892 – 1965)
BANTING, Sir Frederick Grant (1891 – 1941)
BANTING, Sir Frederick Grant (1891 – 1941)
BEST, Charles Herbert (1899 – 1978)
BEST, Charles Herbert (1899 – 1978)

The first clinical application of insulin in the treatment of diabetes. Co-authored by W. R. Campbell, and A. A. Fletcher. Digital facsimile from PubMedCentral at this link.

1923

#3969

The original method as used for the isolation of insulin in semipure form for the treatment of the first clinical cases.

COLLIP, James Bertram (1892 – 1965)
COLLIP, James Bertram (1892 – 1965)

Collip improved insulin.

1924

#3970

Insulin.

BANTING, Sir Frederick Grant (1891 – 1941)
BANTING, Sir Frederick Grant (1891 – 1941)

1927

#3972

Carcinoma of the islands of the pancreas; hyperinsulinism and hypoglycemia.

WILDER, Russell Morse (1885 – 1959) & et al.

R. M. Wilder, F. N. Allan, M. H. Power, and H. E. Robertson reported the occurrence of carcinoma with hyperinsulinism. They also reported the first operation for hyperinsulinism performed on December 2, 1926 by Willia…

1930

#3973

Contribución al estudio sobre la composición quimica de la insulina. Estudio de algunos cuerpos sintéticos solfurados con acción hypoglucemiante.

RUIZ, Celestino L. (1904 – ) & et al.

Discovery of the hypoglycemic effect of certain sulphonamide derivatives. With L. L. Silva and L. Libenson.

1931

#4248

Die nicht diabetischen Glykosurien und Hyperglykämien des älteren Kindes.

FANCONI, Guido (1892 – 1979)
FANCONI, Guido (1892 – 1979)

“Fanconi’s syndrome”, dysfunction of the renal tubules with hypophosphatemia, renal glycosuria, and metabolic disturbances.

1936

#3905

Experimental diabetes insipidus in the monkey.

INGRAM, Walter Robinson (1905 – 1978) & et al.

With C. Fisher and S. W. Ransom.

1936

#4250

Intercapillary lesions in the glomeruli of the kidney.

WILSON, Clifford (1906 – 1997) KIMMELSTIEL, Paul (1900 – 1970)

“Kimmelstiel–Wilson syndrome”. First description of nodular intercapillary glomerulosclerosis, the only known morphological alteration specific, or almost so, for diabetes mellitus.

1936

#3974

Protamine insulinate.

HAGEDORN, Hans Christian (1888 – 1971) & et al.

Hagedorn created NPH insulin and founded Nordisk Insulinlaboratorium, known today as Novo Nordisk. NPH insulin is one of the earliest examples of engineering drug delivery. Hagedorn became interested in modifying the …

1936

#3975

Protamine insulin.

KERR, Robert Bews (1908 – 1997) & et al.

R. B. Kerr, C. H. Best, W. R. Campbell, and A. A. Fletcher advocated the combination of zinc with insulin to delay its absorption rate. Later this was combined with protamine to form protamine zinc insulin.

1937

#1173

Permanent experimental diabetes produced by pituitary (anterior lobe) injections.

YOUNG, Sir Frank George (1908 – 1988)

Anterior pituitary diabetogenic hormone.

1939

#3907

Experimental diabetes insipidus.

BIGGART, Sir John Henry (1905 – 1979) ALEXANDER, George Lionel (1902 – 1970)

Production of diabetes insipidus in dogs by injury to the hypothalamus.

1939

#6231

Prediction and prevention of late pregnancy accidents in diabetes.

WHITE, Priscilla (1900 – 1989) & et al.

First report of hormone treatment. Written with R.S. Titus, E.P. Joslin, and H. Hunt.

1944

#3976.1

Analyse du mécanisme de l’action hypoglycémiante de p-aminobenzène-sulfamido-isopropylthiodiazol (2254 RP).

LOUBATIÈRES, Auguste-Louis (1912 – 1977)

Loubatières initiated work on the hypoglycaemic sulphonamides. See his historical account in Ann. N.Y. Acad. Sci., 1957, 71, 4-11.

1948

#3977

Experimental diabetes produced by the administration of glucose.

DOHAN, Francis Curtis (1907 – 1991) LUKENS, Francis Dring Wetherill (1899 – 1978)

Experimental diabetes produced by artificially-induced hyperglycemia.

1951

#3978

Kliniske undersøgelser med nye retarderet virkende insulin-praeparater.

HALLAS-MØLLER, Knud (1914 – 1984) & et al.

First clinical trials of lente, ultralente, and semilente insulin zinc suspension. See also Science, 1952, 116, 394-98; and J. Amer. med. Assoc., 1952, 150, 1667. With M. Jersild, K. Peterson, and J. Schlichtkrull.

1955

#3978.1

Ein neues antidiabetisches Prinzip. Ergebnisse klinischer Untersuchungen.

FRANKE, Hans (1909 – 1955) FUCHS, J.

Introduction of carbutamide (BZ55), the first of the sulphonylureas. It was followed by tolbutamide and chlorpropamide.

1956

#3978.2

Über die orale Behandlung des Diabetes mellitus mit N-(4-Methyl-Benzolsulfonyl)-N’Butyl-Harnstoff (D 860).

MASKE, Helmut (1921 – )

A Symposium on tolbutamide, introduced by H. Maske.

1957

#3978.3

Pharmacological studies of a new oral hypoglycemic drug.

UNGAR, Georges (1906 – 1977) & et al.

Phenformin, a biguanide formerly used in diabetes. With L. Freedman and S. L. Shapiro. Clinical report on pp. 193-4.

1961

#3978.4

Index zum Diabetes mellitus. Eine internationale Bibliographie.

SCHUMACHER, Joseph (1902 – 1966)

1962

#3978.5

The story of insulin: Forty years of success against diabetes.

WRENSHALL, Gerald Alfred

With G. Hetenyi and W. R. Feasby.

1964

#3979

The history of diabetes mellitus. 2nd ed.

PAPASPYROS, Nikos S.

1973

#14161

Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.

LACY, Paul Easton (1924 – 2005) KEMP, Charles B. KNIGHT, Michael J. SHARP, David W.

Lacy and colleagues showed that transplanation of murine pancreatic islet tissue into the portal vein of diabetic rats of the same inbred strain normalized the sugar levels and urine output of the rats that received t…

1976

#14222

Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.

KOENIG, Ronald Jay PETERSON, Charles M.
CERAMI, Anthony (1940 – )
CERAMI, Anthony (1940 – ) & et al.

The authors studied 5 diabetic patients and first realized that A1c was an ideal index to reveal the overall control of a patient’s blood sugar over the past several months before a doctor’s visit. They were the first…

1979

#13980

Expression in Escherichia coli of chemically synthesized genes for human insulin (plasmid construction / lac operon / fused proteins / radioimmunoassay / peptide purification).

GOEDDEL, David V. (1951 – ) KLEID, Dennis G. CREA, Roberto BOLÍVAR ZAPATA, Francisco Gonzalo (1948 – ) & et al.

Working at Genentech, Kleid and Goeddel and colleagues were the first scientists to apply genetic engineering techniques, incorporating chemically synthesized DNA encoding human insulin into E. coli, that expressed, a…

1982

#3979.1

The discovery of insulin.

BLISS, Michael John William (1941 – 2017)

1987

#3979.2

Histoire illustrée du diabète de l’antiquité à nos jours.

PEUMERY, Jean-Jacques

1989

#9465

Diabetes, its medical and cultural history: Outlines — texts — bibliography. Edited by Dietrich von Engelhardt.

ENGELHARDT, Dietrich von (1941 – )

2009

#9817

Fatal thirst: Diabetes in Britain until insulin.

FURDELL, Elizabeth Lane (1944 – )

2019

#11477

The integrative human microbiome project.

INTEGRATIVE HMP RESEARCH NETWORK CONSORTIUM

Results from this large research consortium show the influence of the microbiome on preterm birth, inflammatory bowel disease, including Crohn's and ulcerative colitis, and prediabetes leading to type II diabetes. (Th…