An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15999 entries, 14040 authors and 1941 subjects. Updated: June 18, 2024


1 entries
  • 11844

A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.

Science, 337, 816-821, 2012.

Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria against bacteriophages could be manipulated, reprogrammed, and guided to make very specific "cuts" on desired target segments of DNA in the lab, making this a gene-targeting and genome-editing tool. This potentially allowed scientists to change or rewrite the genetic code of any organism at will. However, at this point the science was only applied to bacteria. Digital facsimile from PubMedCentral at this link.

In 2020 Charpentier and Doudna were awarded the Nobel Prize in Chemistry “for the development of a method for genome editing.”

(Thanks to Juan Weiss for this reference and its interpretation.)

Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR , NOBEL PRIZES › Nobel Prize in Chemistry, WOMEN, Publications by › Years 2000 -