An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15969 entries, 13962 authors and 1940 subjects. Updated: June 12, 2024

JINEK, Martin

2 entries
  • 11844

A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.

Science, 337, 816-821, 2012.

Order of authorship in the original publication: Jinek, Chylinski, Fonfar, Hauer, Doudna, Charpentier. Doudna, Charpentier and colleagues showed for the first time that the CRISPR evolutionary immune tool of bacteria against bacteriophages could be manipulated, reprogrammed, and guided to make very specific "cuts" on desired target segments of DNA in the lab, making this a gene-targeting and genome-editing tool. This potentially allowed scientists to change or rewrite the genetic code of any organism at will. However, at this point the science was only applied to bacteria.

Digital facsimile from PubMedCentral at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR , WOMEN, Publications by › Years 2000 -
  • 11845

RNA-programmed genome editing in human cells.

eLIFE, 2, e00471, 2013.

Order of authorship in the original publication: Jinek, East, Cheng...Doudna. Doudna and colleagues presented the first demonstration that the CRISPR Cas/Cas9 bacterial editing tool functions could be applied in human cells. The DNA of cells modified in this research were human embryonic kidney cells called HEK-293. The authors summarized the consequences of this paper in the last sentence of their Abstract, which read, "These results show that RNA-programmed genome editing is a facile strategy for introducing site-specific genetic changes in human cells." Digital facsimile from PubMedCentral at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR Gene Editing, WOMEN, Publications by › Years 2000 -